ArticleThe American journal of pathology1993
Platelet activation releases megakaryocyte-synthesized apolipoprotein J, a highly abundant protein in atheromatous lesions.
Article in The American journal of pathology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 67 citations in OpenAlex.
- The Acari Hypothesis, VII: accounting for the comorbidity of allergy with other contemporary medical conditions, especially metabolic syndrome.Frontiers in allergy · 2025Article
- Study on the Mechanism of Platelet-Released Clusterins Inducing Restenosis after Carotid Endarterectomy by Activating TLR3/NF-Journal of healthcare engineering · 2022Article
- Early Prediction Model of Gestational Hypertension by Multi-Biomarkers Before 20 Weeks Gestation.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Distinct Proteomic Signatures in 16 HDL (High-Density Lipoprotein) Subspecies.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Effects of Rosuvastatin on Apolipoprotein J in Balloon-Injured Carotid Artery in Rats.Arquivos brasileiros de cardiologia · 2018Article
- Analysis of the hippocampal proteome in ME7 prion disease reveals a predominant astrocytic signature and highlights the brain-restricted production of clusterin in chronic neurodegeneration.The Journal of biological chemistry · 2014Article
- Plasma proteomic profiles of bovine growth hormone transgenic mice as they age.Transgenic research · 2011Article
- Identification of human plasma proteins as major clients for the extracellular chaperone clusterin.The Journal of biological chemistry · 2010Article
- Development of reverse phase protein microarrays for the validation of clusterin, a mid-abundant blood biomarker.Proteome science · 2009Article
- Functional and structural properties of lipid-associated apolipoprotein J (clusterin).The Biochemical journal · 1999Article
- The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse.The Journal of clinical investigation · 1999Article
- Prothrombin deficiency results in embryonic and neonatal lethality in mice.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Tubular up-regulation of clusterin mRNA in murine lupus-like nephritis.The American journal of pathology · 1998Article
- Apolipoprotein J (clusterin) induces cholesterol export from macrophage-foam cells: a potential anti-atherogenic function?The Biochemical journal · 1998Article
- Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio.The Journal of clinical investigation · 1997Article
- Expression of the putative proto-oncogene His-1 in normal and neoplastic tissues.The American journal of pathology · 1997Article
- Clusterin promotes the aggregation and adhesion of renal porcine epithelial cells.The Journal of clinical investigation · 1995Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Apolipoprotein J (apoJ) is an abundant glycoprotein in many biological fluids, and its constitutive high level synthesis is characteristic of many epithelial cells exposed to harsh fluids such as urine, bile, and gastric secretions. In addition, dramatic induction of apoJ occurs in cells surrounding several kinds of pathological lesions. Because platelets and circulating inflammatory cells represent critical elements in numerous pathological processes, we evaluated bone marrow cells for the presence of apoJ. Based upon messenger RNA in situ hybridization and immunofluorescent protein detection, high-level apoJ gene expression and protein accumulation occurred exclusively in mature megakaryocytes. Our results indicate that apoJ is stored in platelet granules and is released into extracellular fluid following platelet activation. Because atheromatous plaque development involves platelet aggregation and activation, we looked for and found abundant apoJ protein in advanced human atheromatous lesions. Thus, platelet sequestration and activation may lead to the rapid deployment of apoJ into sites of vascular injury. We hypothesize that platelet-derived apoJ participates in both short-term wound repair processes and chronic pathogenic processes at vascular interfaces.
Indexed as
Identifiers
8362975PMC1887200W239434478What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.