ArticleInfection and immunity1993
Implication of phagosome-lysosome fusion in restriction of Mycobacterium avium growth in bone marrow macrophages from genetically resistant mice.
Article in Infection and immunity, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 111 citations in OpenAlex.
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- Reversible lipid accumulation and associated division arrest of Mycobacterium avium in lipoprotein-induced foamy macrophages may resemble key events during latency and reactivation of tuberculosis.Infection and immunity · 2014Article
- Phosphorylation of mycobacterial PcaA inhibits mycolic acid cyclopropanation: consequences for intracellular survival and for phagosome maturation block.The Journal of biological chemistry · 2012Article
- The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition.PLoS pathogens · 2012Article
- Brucella abortus ornithine lipids are dispensable outer membrane components devoid of a marked pathogen-associated molecular pattern.PloS one · 2011Article
- Redundant hydrogen peroxide scavengers contribute to Salmonella virulence and oxidative stress resistance.Journal of bacteriology · 2009Article
- The glyceraldehyde-3-phosphate dehydrogenase and the small GTPase Rab 2 are crucial for Brucella replication.PLoS pathogens · 2009Article
- The early phagosomal stage of Francisella tularensis determines optimal phagosomal escape and Francisella pathogenicity island protein expression.Infection and immunity · 2008Article
- Brucella control of dendritic cell maturation is dependent on the TIR-containing protein Btp1.PLoS pathogens · 2008Article
- Slc11a1, formerly Nramp1, is expressed in dendritic cells and influences major histocompatibility complex class II expression and antigen-presenting cell function.Infection and immunity · 2007Article
- I/St mice hypersusceptible to Mycobacterium tuberculosis are resistant to M. avium.Infection and immunity · 2007Article
- Autophagy-mediated reentry of Francisella tularensis into the endocytic compartment after cytoplasmic replication.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- The Salmonella effector protein PipB2 is a linker for kinesin-1.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Brucella coopts the small GTPase Sar1 for intracellular replication.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum.The Journal of experimental medicine · 2003Article
- Mycobacterium avium genes expressed during growth in human macrophages detected by selective capture of transcribed sequences (SCOTS).Infection and immunity · 2002Article
- SLC11A1 (formerly NRAMP1) and disease resistance.Cellular microbiology · 2001Review
- Stable transfection of the bovine NRAMP1 gene into murine RAW264.7 cells: effect on Brucella abortus survival.Infection and immunity · 2001Article
- Natural-resistance-associated macrophage protein 1 is an H+/bivalent cation antiporter.The Biochemical journal · 2001Article
- Nramp1 is expressed in neurons and is associated with behavioural and immune responses to stress.Neurogenetics · 2001Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability of the host to resist infection to a variety of intracellular pathogens, including mycobacteria, is strongly dependent upon the expression of the Bcg gene. Mouse strains which express the resistance phenotype (Bcgr) restrict bacterial growth, whereas susceptible strains (Bcgs) allow bacterial growth. Expression of the Bcg allele is known to influence the priming of host macrophages (M phi s) for bactericidal function. In the present work, bone marrow-derived M phi s from congenic BALB/c (Bcgs) and C.D2 (BALB/c.Bcgr) mice were infected with the virulent strain Mycobacterium avium TMC 724 to define the mechanism involved in growth restriction of M. avium. By combining CFU measurements and ultrastructural analyses, we show that growth of this bacterium is restricted in marrow M phi s from resistant mice. Using acid phosphatase as a lysosomal marker, we provide evidence that the hydrolytic activity of M phi s, as measured by the capacity of lysosomes to fuse with and transfer active hydrolytic enzymes to phagosomes in which M. avium resides, is an expression of the Bcg gene and that this phenomenon is a key antibacterial activity responsible for growth restriction of M. avium: (i) the percentage of phagosome-lysosome fusions was twice as high in Bcgr M phi s as in Bcgs M phi s, and (ii) the percentage of intact viable bacteria residing in acid phosphatase-negative phagosomes was twice as low in Bcgr M phi s as in the Bcgs counterparts. These differences are not due to a lower activity of the enzyme in Bcgr M phi s. The mechanism by which the Bcg gene exerts control over the phagolysosomal fusion is discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.