ArticleInfection and immunity1993
Natural killer cells do not play a dominant role in CD4+ subset differentiation in Candida albicans-infected mice.
Article in Infection and immunity, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Vaccine-Induced Immunological Memory in Invasive Fungal Infections - A Dream so Close yet so Far.Frontiers in immunology · 2021Review
- Integrating GWAS with bulk and single-cell RNA-sequencing reveals a role for LY86 in the anti-Candida host response.PLoS pathogens · 2020Article
- Immune defence against Candida fungal infections.Nature reviews. Immunology · 2015Review
- Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection.PLoS pathogens · 2014Article
- Organ-specific innate immune responses in a mouse model of invasive candidiasis.Journal of innate immunity · 2011Article
- Genetic analysis of innate immunity in resistance to Candida albicans.Genes and immunity · 2004Review
- Vaginal T lymphocyte population kinetics during experimental vaginal candidosis: evidence for a possible role of CD8+ T cells in protection against vaginal candidosis.Clinical and experimental immunology · 2003Article
- Characteristics of invasive candidiasis in gamma interferon- and interleukin-4-deficient mice: role of macrophages in host defense against Candida albicans.Infection and immunity · 1998Article
- Endogenous interleukin 4 is required for development of protective CD4+ T helper type 1 cell responses to Candida albicans.The Journal of experimental medicine · 1998Article
- Macrophages in resistance to candidiasis.Microbiology and molecular biology reviews : MMBR · 1997Review
- Production and function of cytokines in natural and acquired immunity to Candida albicans infection.Microbiological reviews · 1995Review
- Gamma delta T cell-induced nitric oxide production enhances resistance to mucosal candidiasis.Nature medicine · 1995Article
- T helper cell dichotomy to Candida albicans: implications for pathology, therapy, and vaccine design.Immunologic research · 1995Review
- Differential Th1 and Th2 cell responses in male and female BALB/c mice infected with coxsackievirus group B type 3.Journal of virology · 1994Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of in vivo administration of monoclonal antibodies against NK-1.1-bearing cells on the early production of gamma interferon (IFN-gamma) in vitro and development of Th1-associated immunity were studied in mice infected with a live vaccine strain of Candida albicans. At 1 and 4 days postinfection, natural killer (NK) cell-enriched fractions from the spleens of antibody-treated mice displayed a dramatic reduction in 5E6+ lymphocytes and negligible anti-YAC-1 cytotoxic activity in vitro. Nevertheless, the frequency of IFN-gamma-producing cells in those fractions was reduced by less than half, on average, by anti-NK-1.1 treatment in vivo. In addition, the antibody-treated and infected mice demonstrated unchanged T helper cell responses, as measured by yeast-specific footpad reactions, resistance to reinfection, occurrence of antibodies of different isotypes, and production in vitro of interleukin-2 (IL-2), IFN-gamma, IL-4, and IL-10 by CD4+ cells. Therefore, although NK cells may contribute to early IFN-gamma production in Candida-vaccinated mice, these cells apparently do not play a dominant role in the qualitative development of yeast-specific T helper responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.