ArticleInfection and immunity1993
Cloning and characterization of ECE1, a gene expressed in association with cell elongation of the dimorphic pathogen Candida albicans.
Article in Infection and immunity, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers.
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131 citing papers in PubMed, 245 citations in OpenAlex.
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- Image-based quantification of Candida albicans filamentation and hyphal length using the open-source visual programming language JIPipe.FEMS yeast research · 2025Article
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- Macrophage pyroptosis induced by Candida albicans.Pathogens and disease · 2024Review
- Candida albicans induces neutrophil extracellular traps and leucotoxic hypercitrullination via candidalysin.EMBO reports · 2023Article
- Dose-Dependent Inhibitory Effect of ProbioticPathogens (Basel, Switzerland) · 2023Article
- Fungal resilience and host-pathogen interactions: Future perspectives and opportunities.Parasite immunology · 2023Review
- Nature of β-1,3-Glucan-Exposing Features on Candida albicans Cell Wall and Their Modulation.mBio · 2022Article
- Candidalysin Is the Hemolytic Factor ofToxins · 2022Article
- Is Candida albicans an opportunistic oncogenic pathogen?PLoS pathogens · 2022Article
- The novel antifungal agent AB-22 displays in vitro activity against hyphal growth and biofilm formation in Candida albicans and potency for treating systemic candidiasis.Journal of microbiology (Seoul, Korea) · 2022Article
71 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The gene ECE1 (extent of cell elongation 1) was isolated by differential hybridization screening of a Candida albicans cDNA library by using probes derived from populations of yeast cells or hyphae. Expression of this gene was not detected when C. albicans grew as a budding yeast cell but was observed within 30 min after cells had been induced to form hyphae. In all strains tested, regardless of the induction signal, ECE1 expression correlated with the extent of cell elongation. The genomic version of ECE1 was cloned and sequenced. The deduced 271-amino-acid polypeptide consisted of eight tandem repeats of a degenerate 34-amino-acid sequence which contained no discernible homology with other known sequences. An ECE1 null mutant displayed no morphological alterations, which demonstrated that ECE1 is not essential for cell elongation or hypha formation despite the strict morphological association of its expression.
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