ReviewDigestive diseases and sciences1993
Intestinal epithelial function: the case for immunophysiological regulation. Implications for disease (2).
Review in Digestive diseases and sciences, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Coordinated regulation of colonic fluid and mucus secretion.Frontiers in pharmacology · 2026Review
- Lipopolysaccharides modulate intestinal epithelial permeability and inflammation in a species-specific manner.Gut microbes · 2020Article
- Deciphering the pathophysiology of irritable bowel syndrome and functional gastrointestinal disorders-an alternative model for pathogenesis: cytokine controlled transepithelial multi-feedback loop.Translational gastroenterology and hepatology · 2017Review
- Salivary epidermal growth factor plays a role in protection of ileal mucosal integrity.Digestive diseases and sciences · 1997Article
- The intestinal epithelial cell: immunological aspects.Springer seminars in immunopathology · 1997Review
- Interleukin-8 production by the human colon epithelial cell line HT-29: modulation by interleukin-13.British journal of pharmacology · 1996Article
- Inducible nitric oxide synthase activity and expression in a human colonic epithelial cell line, HT-29.British journal of pharmacology · 1995Article
- Regulation of chloride secretion in mammalian colon.Irish journal of medical science · 1994Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Substantial amounts of data have been reported showing a role for immunomodulation of epithelial function (particularly ion secretion and permeability) using animal models of anaphylactic reactions. In part one of this review we outlined the main immune cell types and mediators/cytokines that are currently known to influence epithelial physiology either directly, or indirectly via an intermediate cell type. Here we will expand on the significance of these studies and show how antigenic activation of the mucosal immune system can evoke changes in epithelial function that may be beneficial to the host by mediating loss/inactivation of the antigen. However, a continued and inappropriate immune stimulation can lead to pathophysiological reactions and disease. Thus, we will present data on immune regulation of epithelial function with direct applicability to understanding the mechanism underlying human intestinal inflammatory and secretory disease. Finally, we highlight key strategic points in the cascade of immune events that can control epithelial function and thus may be of relevance in the formulation of new therapeutic approaches to intestinal inflammation.
Indexed as
Identifiers
8359088What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.