ArticleDigestive diseases and sciences1993
Multiple vitamin status in Crohn's disease. Correlation with disease activity.
Article in Digestive diseases and sciences, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.
- Associations between Folate and Vitamin B12 Levels and Inflammatory Bowel Disease: A Meta-Analysis.Nutrients · 2017Pooled it
- The Role of Vitamin C in Selected Autoimmune and Immune-Mediated Diseases: Exploring Potential Therapeutic Benefits.International journal of molecular sciences · 2025Review
- Cystic fibrosis and inflammatory bowel disease: parallels in gut physiology and microbiota.Journal of bacteriology · 2025Review
- Subnormal Serum Liver Enzyme Levels: A Review of Pathophysiology and Clinical Significance.Journal of clinical and translational hepatology · 2024Review
- A retrospective analysis of vitamin B6 deficiency and associated changes of gut microbes in Crohn's disease.European journal of clinical nutrition · 2023Article
- The interplay between the microbiome and colonic immune system in checkpoint inhibitor therapy.Frontiers in microbiomes · 2023Review
- Relevance of Biotin Deficiency in Patients with Inflammatory Bowel Disease and Utility of Serum 3 Hydroxyisovaleryl Carnitine as a Practical Everyday Marker.Journal of clinical medicine · 2022Article
- Zinc and Selenium in Inflammatory Bowel Disease: Trace Elements with Key Roles?Biological trace element research · 2021Review
- Protective Effects ofFrontiers in immunology · 2020Article
- The reduction of faecal calprotectin during exclusive enteral nutrition is lost rapidly after food re-introduction.Alimentary pharmacology & therapeutics · 2019Observational
- Identification of transmembrane protein 237 as a novel interactor with the intestinal riboflavin transporter-3 (RFVT-3): role in functionality and cell biology.American journal of physiology. Cell physiology · 2019Article
- Review
- Effect of the proinflammatory cytokine TNF-α on intestinal riboflavin uptake: inhibition mediated via transcriptional mechanism(s).American journal of physiology. Cell physiology · 2018Article
- Microbiota dysbiosis in inflammatory bowel diseases: in silico investigation of the oxygen hypothesis.BMC systems biology · 2017Article
- Role of MicroRNA-423-5p in posttranscriptional regulation of the intestinal riboflavin transporter-3.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- Vitamins and Minerals in Inflammatory Bowel Disease.Gastroenterology clinics of North America · 2017Review
- Structure/functional aspects of the human riboflavin transporter-3 (American journal of physiology. Cell physiology · 2017Article
- Gastrointestinal and Hepatic Complications of Immune Checkpoint Inhibitors.Current gastroenterology reports · 2017Review
- A Complex Interplay of Vitamin B1 and B6 Metabolism with Cognition, Brain Structure, and Functional Connectivity in Older Adults.Frontiers in neuroscience · 2017Article
- Wernicke's encephalopathy after total parenteral nutrition in patients with Crohn's disease.Intestinal research · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We measured serum, blood, or red cell concentrations of various vitamins in 24 patients with Crohn's disease who had been free from any nutritional treatment, and compared them with those in 24 healthy controls. Twelve of the patients were affected in the small bowel only, two in the large bowel only, and the remaining 10 in both the small and large bowel. The fat-soluble vitamins A and E were significantly decreased in patients with Crohn's disease compared to controls. Among the water-soluble vitamins, vitamins B1, B2 and B6 and folic acid were more depleted in patients with Crohn's disease than in the controls, whereas vitamins B12 and C, nicotinic acid, and biotin were not different between the two groups, and pantothenic acid was increased in patients with Crohn's disease. In addition, vitamin B2 and nicotinic acid showed a negative correlation with the Crohn's disease activity index. These findings suggest that there is a variety of vitamin deficiencies in Crohn's disease prior to treatment and also that concentrations of some vitamins, such as vitamin B2 and nicotinic acid, may reflect the severity of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.