ArticleMolecular and cellular biology1993
Saccharomyces cerevisiae BUF protein binds to sequences participating in DNA replication in addition to those mediating transcriptional repression (URS1) and activation.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 53 citations in OpenAlex.
- Genomic analysis of stationary-phase and exit in Saccharomyces cerevisiae: gene expression and identification of novel essential genes.Molecular biology of the cell · 2004Article
- Replication protein A is sequentially phosphorylated during meiosis.Nucleic acids research · 2001Article
- Combinatorial regulation of phospholipid biosynthetic gene expression by the UME6, SIN3 and RPD3 genes.Nucleic acids research · 2000Article
- Nitrogen catabolite repression in Saccharomyces cerevisiae.Molecular biotechnology · 1999Review
- Article
- Role of UME6 in transcriptional regulation of a DNA repair gene in Saccharomyces cerevisiae.Molecular and cellular biology · 1997Article
- Expression of an ortholog of replication protein A1 (RPA1) is induced by gibberellin in deepwater rice.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Analysis of a meiosis-specific URS1 site: sequence requirements and involvement of replication protein A.Molecular and cellular biology · 1997Article
- Denaturation of the simian virus 40 origin of replication mediated by human replication protein A.Molecular and cellular biology · 1997Article
- Stimulation of yeast meiotic gene expression by the glucose-repressible protein kinase Rim15p.Molecular and cellular biology · 1997Article
- Combinatorial regulation of the Saccharomyces cerevisiae CAR1 (arginase) promoter in response to multiple environmental signals.Molecular and cellular biology · 1996Article
- The 70 kDa subunit of replication protein A is required for the G1/S and intra-S DNA damage checkpoints in budding yeast.Nucleic acids research · 1996Article
- Participation of the yeast activator Abf1 in meiosis-specific expression of the HOP1 gene.Molecular and cellular biology · 1996Article
- The yeast UME6 gene is required for both negative and positive transcriptional regulation of phospholipid biosynthetic gene expression.Nucleic acids research · 1996Article
- UME6 is a central component of a developmental regulatory switch controlling meiosis-specific gene expression.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Regulation of nuclear genes encoding mitochondrial proteins in Saccharomyces cerevisiae.Journal of bacteriology · 1995Article
- A bipartite operator interacts with a heat shock element to mediate early meiotic induction of Saccharomyces cerevisiae HSP82.Molecular and cellular biology · 1995Article
- A DNA binding factor (UBF) interacts with a positive regulatory element in the promoters of genes expressed during meiosis and vegetative growth in yeast.Nucleic acids research · 1995Article
- A 15-base-pair element activates the SPS4 gene midway through sporulation in Saccharomyces cerevisiae.Molecular and cellular biology · 1995Article
- The upstream region of the FOX3 gene encoding peroxisomal 3-oxoacyl-coenzyme A thiolase in Saccharomyces cerevisiae contains ABF1- and replication protein A-binding sites that participate in its regulation by glucose repression.Molecular and cellular biology · 1995Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The heteromeric BUF protein was originally shown to bind to URS1 elements which are situated upstream of many genes in Saccharomyces cerevisiae and mediate negative control of their transcription. Among the genes regulated through the URS1 site and the proteins interacting with it are those participating in carbon, nitrogen, and inositol metabolism; electron transport; meiosis; sporulation; and mating-type switching. We show here that pure BUF protein, in addition to binding to the negatively acting URS1 site, also binds to CAR1 sequences supporting transcriptional activation (upstream activation sequences). To determine the BUF protein structure, we cloned and sequenced the BUF1 and BUF2 genes and found them to be identical to the RF-A (RP-A) gene whose products participate in yeast DNA replication as single-stranded DNA binding proteins. These data argue that BUF protein-binding sites serve multiple roles in transcription and replication.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.