ArticleMolecular and cellular biology1993
The ht beta gene encodes a novel CACCC box-binding protein that regulates T-cell receptor gene expression.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 65 citations in OpenAlex.
- Loss of ZNF148 enhances insulin secretion in human pancreatic β cells.JCI insight · 2023Article
- Zinc finger protein 148 is dispensable for primitive and definitive hematopoiesis in mice.PloS one · 2013Article
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- Unique DNA methylome profiles in CpG island methylator phenotype colon cancers.Genome research · 2012Article
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- Over-expression of the transcription factor, ZBP-89, leads to enhancement of the C2C12 myogenic program.Biochimica et biophysica acta · 2009Article
- HIV-1 sequence evolution in vivo after superinfection with three viral strains.Retrovirology · 2007Article
- Activation and repression of interleukin-12 p40 transcription by erythroid Kruppel-like factor in macrophages.The Journal of biological chemistry · 2004Article
- Stat3 enhances vimentin gene expression by binding to the antisilencer element and interacting with the repressor protein, ZBP-89.Oncogene · 2004Article
- ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1.Nucleic acids research · 2003Article
- Regulation of epithelial cell growth by ZBP-89: potential relevance in pancreatic cancer.International journal of gastrointestinal cancer · 2002Review
- PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters.The Biochemical journal · 2000Article
- Definition of a T-cell receptor beta gene core enhancer of V(D)J recombination by transgenic mapping.Molecular and cellular biology · 2000Article
- Expression of the mouse pre-T cell receptor alpha gene is controlled by an upstream region containing a transcriptional enhancer.The Journal of experimental medicine · 1999Article
- Article
- The human ZBP-89 homolog, located at chromosome 3q21, represses gastrin gene expression.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
- HUB1, a novel Krüppel type zinc finger protein, represses the human T cell leukemia virus type I long terminal repeat-mediated expression.Nucleic acids research · 1997Article
- ZBP-89, a Krüppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter.Molecular and cellular biology · 1996Article
- Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells.Molecular and cellular biology · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A gene encoding a novel CACCC box-binding protein that binds to the promoter region of the human T-cell receptor (TCR) V beta 8.1 gene and the mouse TCR alpha gene silencer has been cloned. This gene, termed ht beta, contains four zinc fingers of the class Cys2-X12-His2 that may be responsible for DNA binding and a highly negatively charged region that defines a putative transcriptional activation domain. Analysis of the expression of ht beta mRNA revealed similar expression levels and patterns in various cell lines. The bacterially expressed ht beta protein can bind to the CACCC box in both the human TCR V beta 8.1 gene promoter and the mouse TCR alpha gene silencer. The CACCC box is essential for efficient transcription of the V beta 8.1 promoter. Cotransfection with an ht beta expression plasmid and a reporter vector indicated that ht beta can activate human TCR V beta 8.1 gene transcription. ht beta also is able to counteract the silencing effect of the mouse TCR alpha gene silencer. The CACCC box has been found in almost all V beta 8.1 gene subfamily members and in both TCR alpha and beta gene enhancers in humans and mice. These results suggest that the CACCC box-binding protein may have an important regulatory function for TCR gene expression in alpha beta T cells versus gamma delta T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.