ArticleMolecular and cellular biology1993
Control of BEK and K-SAM splice sites in alternative splicing of the fibroblast growth factor receptor 2 pre-mRNA.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 91 citations in OpenAlex.
- Intronic Single Nucleotide Polymorphisms in FGFR2 Gene Association With Non-Syndromic Mandibular Retrognathism.Orthodontics & craniofacial research · 2026Article
- Fgf9 promotes incisor dental epithelial stem cell survival and enamel formation.Stem cell research & therapy · 2024Article
- Expansion of the complex genotypic and phenotypic spectrum of FGFR2-associated neurocutaneous syndromes.Human genetics · 2024Article
- Genetic Causes of Craniosynostosis: An Update.Molecular syndromology · 2019Review
- The Role of Fibroblast Growth Factors in Tooth Development and Incisor Renewal.Stem cells international · 2018Review
- FGF signaling: diverse roles during cochlear development.BMB reports · 2017Review
- Revisiting Crouzon syndrome: reviewing the background and management of a multifaceted disease.Oral and maxillofacial surgery · 2014Review
- Fibroblast growth factor signaling in mammalian tooth development.Odontology · 2014Review
- Comparison of genetic variation of breast cancer susceptibility genes in Chinese and German populations.European journal of human genetics : EJHG · 2013Article
- Palifermin for the protection and regeneration of epithelial tissues following injury: new findings in basic research and pre-clinical models.Journal of cellular and molecular medicine · 2013Review
- Activating somatic FGFR2 mutations in breast cancer.PloS one · 2013Article
- Alternative Splicing of Fibroblast Growth Factor Receptor IgIII Loops in Cancer.Journal of nucleic acids · 2012Article
- Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative exon selection.PloS one · 2010Article
- Combined use of MS2 and PP7 coat fusions shows that TIA-1 dominates hnRNP A1 for K-SAM exon splicing control.Journal of biomedicine & biotechnology · 2009Article
- Lacrimo-auriculo-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway.Molecular and cellular biology · 2007Article
- Article
- Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.The Journal of biological chemistry · 2006Article
- A stem structure in fibroblast growth factor receptor 2 transcripts mediates cell-type-specific splicing by approximating intronic control elements.Molecular and cellular biology · 2003Article
- Expression of the IIIc variant of FGF receptor-1 confers mitogenic responsiveness to heparin and FGF-5 in TAKA-1 pancreatic ductal cells.International journal of pancreatology : official journal of the International Association of Pancreatology · 2001Article
- Fibroblast growth factors.Genome biology · 2001Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fibroblast growth factor receptor 2 gene pre-mRNA can be spliced by using either the K-SAM exon or the BEK exon. The exon chosen has a profound influence on the ligand-binding specificity of the receptor obtained. Cells make a choice between the two alternative exons by controlling use of both exons. Using fibroblast growth factor receptor 2 minigenes, we have shown that in cells normally using the K-SAM exon, the BEK exon is not used efficiently even in the absence of the K-SAM exon. This is because these cells apparently express a titratable repressor of BEK exon use. In cells normally using the BEK exon, the K-SAM exon is not used efficiently even in the absence of a functional BEK exon. Three purines in the K-SAM polypyrimidine tract are at least in part responsible for this, as their mutation to pyrimidines leads to efficient use of the K-SAM exon, while mutating the BEK polypyrimidine tract to include these purines stops BEK exon use.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.