ArticleMolecular and cellular biology1993
Elements regulating an alternatively spliced exon of the rat fibronectin gene.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 61 citations in OpenAlex.
- TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cells.Nature communications · 2025Article
- Article
- Fibronectin maintains the balance between hemostasis and thrombosis.Cellular and molecular life sciences : CMLS · 2016Review
- The adipogenic transcriptional cofactor ZNF638 interacts with splicing regulators and influences alternative splicing.Journal of lipid research · 2014Article
- RNA Bind-n-Seq: quantitative assessment of the sequence and structural binding specificity of RNA binding proteins.Molecular cell · 2014Article
- New insights into form and function of fibronectin splice variants.The Journal of pathology · 2008Review
- Variation in sequence and organization of splicing regulatory elements in vertebrate genes.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- An intronic enhancer regulates splicing of the twintron of Drosophila melanogaster prospero pre-mRNA by two different spliceosomes.Molecular and cellular biology · 2004Article
- Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulation.Molecular and cellular biology · 2003Article
- A vertebrate RNA-binding protein Fox-1 regulates tissue-specific splicing via the pentanucleotide GCAUG.The EMBO journal · 2003Article
- Finding signals that regulate alternative splicing in the post-genomic era.Genome biology · 2002Review
- Mechanical tension controls granulation tissue contractile activity and myofibroblast differentiation.The American journal of pathology · 2001Article
- Control of hnRNP A1 alternative splicing: an intron element represses use of the common 3' splice site.Molecular and cellular biology · 2000Article
- Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein.Molecular and cellular biology · 2000Article
- Splicing enhancement in the yeast rp51b intron.RNA (New York, N.Y.) · 2000Article
- High-molecular-weight fibronectin synthesized by adenoid cystic carcinoma cells of salivary gland origin.Japanese journal of cancer research : Gann · 1999Article
- Donor site competition is involved in the regulation of alternative splicing of the rat beta-tropomyosin pre-mRNA.RNA (New York, N.Y.) · 1999Article
- hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells.Molecular and cellular biology · 1999Article
- Muscle-specific splicing of a heterologous exon mediated by a single muscle-specific splicing enhancer from the cardiac troponin T gene.Molecular and cellular biology · 1998Article
- Alternative splicing of the fibronectin EIIIB exon depends on specific TGCATG repeats.Molecular and cellular biology · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have investigated the regulation of splicing of one of the alternatively spliced exons in the rat fibronectin gene, the EIIIB exon. This 273-nucleotide exon is excluded by some cells and included to various degrees by others. We find that EIIIB is intrinsically poorly spliced and that both its exon sequences and its splice sites contribute to its poor recognition. Therefore, cells which recognize the EIIIB exon must have mechanisms for improving its splicing. Furthermore, in order for EIIB to be regulated, a balance must exist between the EIIIB splice sites and those of its flanking exons. Although the intron upstream of EIIIB does not appear to play a role in the recognition of EIIIB for splicing, the intron downstream contains sequence elements which can promote EIIIB recognition in a cell-type-specific fashion. These elements are located an unusually long distance from the exon that they regulate, more than 518 nucleotides downstream from EIIIB, and may represent a novel mode of exon regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.