ArticleMolecular and cellular biology1993
A small segment of the MAT alpha 1 transcript promotes mRNA decay in Saccharomyces cerevisiae: a stimulatory role for rare codons.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
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Who cites it
104 citing papers in PubMed, 189 citations in OpenAlex.
- Cytoplasmic mRNA decay and quality control machineries in eukaryotes.Nature reviews. Genetics · 2025Review
- Atlas of mRNA translation and decay for bacteria.Nature microbiology · 2023Article
- Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.Nature communications · 2022Article
- Ribosome dynamics and mRNA turnover, a complex relationship under constant cellular scrutiny.Wiley interdisciplinary reviews. RNA · 2021Review
- Ribosome states signal RNA quality control.Molecular cell · 2021Review
- Plant RNases T2, but not Dicer-like proteins, are major players of tRNA-derived fragments biogenesis.Nucleic acids research · 2019Article
- Structural and molecular mechanisms for the control of eukaryotic 5'-3' mRNA decay.Nature structural & molecular biology · 2018Review
- Codon optimality, bias and usage in translation and mRNA decay.Nature reviews. Molecular cell biology · 2018Review
- Article
- The link between adjacent codon pairs and mRNA stability.BMC genomics · 2017Article
- Synonymous Codons: Choose Wisely for Expression.Trends in genetics : TIG · 2017Review
- Analysis of the association between codon optimality and mRNA stability in Schizosaccharomyces pombe.BMC genomics · 2016Article
- Multiple Transcript Properties Related to Translation Affect mRNA Degradation Rates inG3 (Bethesda, Md.) · 2016Article
- The Yin and Yang of codon usage.Human molecular genetics · 2016Review
- Conditional regulation of Puf1p, Puf4p, and Puf5p activity alters YHB1 mRNA stability for a rapid response to toxic nitric oxide stress in yeast.Molecular biology of the cell · 2015Article
- Article
- Carbon source-dependent alteration of Puf3p activity mediates rapid changes in the stabilities of mRNAs involved in mitochondrial function.Nucleic acids research · 2014Article
- The CR3 motif of Rrp44p is important for interaction with the core exosome and exosome function.Nucleic acids research · 2012Article
- RNA degradation in Saccharomyces cerevisae.Genetics · 2012Review
- Synthetic RNA modules for fine-tuning gene expression levels in yeast by modulating RNase III activity.Nucleic acids research · 2011Article
44 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Differences in decay rates of eukaryotic transcripts can be determined by discrete sequence elements within mRNAs. Through the analysis of chimeric transcripts and internal deletions, we have identified a 65-nucleotide segment of the MAT alpha 1 mRNA coding region, termed the MAT alpha 1 instability element, that is sufficient to confer instability to a stable PGK1 reporter transcript and that accelerates turnover of the unstable MAT alpha 1 mRNA. This 65-nucleotide element is composed of two parts, one located within the 5' 33 nucleotides and the second located in the 3' 32 nucleotides. The first part, which can be functionally replaced by sequences containing rare codons, is unable to promote rapid decay by itself but can enhance the action of the 3' 32 nucleotides (positions 234 to 266 in the MAT alpha 1 mRNA) in accelerating turnover. A second portion of the MAT alpha 1 mRNA (nucleotides 265 to 290) is also sufficient to destabilize the PGK1 reporter transcript when positioned 3' of rare codons, suggesting that the 3' half of the MAT alpha 1 instability element is functionally reiterated within the MAT alpha 1 mRNA. The observation that rare codons are part of the 65-nucleotide MAT alpha 1 instability element suggests possible mechanisms through which translation and mRNA decay may be linked.
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