ArticleMolecular and cellular biology1993
An E box mediates activation and repression of the acetylcholine receptor delta-subunit gene during myogenesis.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 87 citations in OpenAlex.
- The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization.Molecular cell · 2010Article
- The core binding factor CBF negatively regulates skeletal muscle terminal differentiation.PloS one · 2010Article
- S. macrurus myogenic regulatory factors (MRFs) induce mammalian skeletal muscle differentiation; evidence for functional conservation of MRFs.The International journal of developmental biology · 2009Article
- Article
- Expression of myogenic regulatory factors in the muscle-derived electric organ of Sternopygus macrurus.The Journal of experimental biology · 2008Article
- Accelerated response of the myogenin gene to denervation in mutant mice lacking phosphorylation of myogenin at threonine 87.Molecular and cellular biology · 2004Article
- Aberrant development of motor axons and neuromuscular synapses in MyoD-null mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- A zinc finger transcription factor, alphaA-crystallin binding protein 1, is a negative regulator of the chondrocyte-specific enhancer of the alpha1(II) collagen gene.Molecular and cellular biology · 2000Article
- Independent repressor domains in ZEB regulate muscle and T-cell differentiation.Molecular and cellular biology · 1999Article
- Myogenin induces a shift of enzyme activity from glycolytic to oxidative metabolism in muscles of transgenic mice.The Journal of cell biology · 1999Article
- cdk1- and cdk2-mediated phosphorylation of MyoD Ser200 in growing C2 myoblasts: role in modulating MyoD half-life and myogenic activity.Molecular and cellular biology · 1999Article
- Synapse-specific and neuregulin-induced transcription require an ets site that binds GABPalpha/GABPbeta.Genes & development · 1998Article
- Implication of a multisubunit Ets-related transcription factor in synaptic expression of the nicotinic acetylcholine receptor.The EMBO journal · 1998Article
- ZEB, a vertebrate homolog of Drosophila Zfh-1, is a negative regulator of muscle differentiation.The EMBO journal · 1997Article
- beta43': An enhancer displaying neural-restricted activity is located in the 3'-untranslated exon of the rat nicotinic acetylcholine receptor beta4 gene.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Cyclin-mediated inhibition of muscle gene expression via a mechanism that is independent of pRB hyperphosphorylation.Molecular and cellular biology · 1996Article
- Accumulation in fetal muscle and localization to the neuromuscular junction of cAMP-dependent protein kinase A regulatory and catalytic subunits RI alpha and C alpha.The Journal of cell biology · 1996Article
- Differences between MyoD DNA binding and activation site requirements revealed by functional random sequence selection.Molecular and cellular biology · 1996Article
- Flanking sequences modulate the cell specificity of M-CAT elements.Molecular and cellular biology · 1996Article
- Identification and characterization of a 47 base pair activity-dependent enhancer of the rat nicotinic acetylcholine receptor delta-subunit promoter.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The genes encoding the skeletal muscle acetylcholine receptor (AChR) are induced during muscle development and are regulated subsequently by innervation. Because both the initiation and the subsequent regulation of AChR expression are controlled by transcriptional mechanisms, an understanding of the steps that regulate AChR expression following innervation is likely to require knowledge of the pathway that activates AChR genes during myogenesis. Thus, we sought to identify the cis-acting sequences that regulate expression of the AChR delta-subunit gene during muscle differentiation. We transfected muscle and nonmuscle cell lines with gene fusions between 5'-flanking DNA from the AChR delta-subunit gene and the human growth hormone gene, and we show here that 148 bp of 5'-flanking DNA from the AChR delta-subunit gene contains two regulatory elements that control muscle-specific gene expression. One element is an E box, which is important both for activation of the delta-subunit gene in myotubes and for its repression in myoblasts and nonmuscle cells. Mutation of this E box, which prevents binding of MyoD-E2A and myogenin-E2A heterodimers, decreases expression in myotubes and increases expression in myoblasts and nonmuscle cells. An E-box binding activity, which does not contain MyoD, myogenin, or E2A proteins, is present in muscle and nonmuscle cells and may be responsible for repressing the delta-subunit gene in myoblasts and nonmuscle cells. An enhancer, which lacks E boxes, is also required for expression of the delta-subunit gene but does not confer muscle-specific expression.
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