ArticleThe Journal of cell biology1993
Preventing re-replication of DNA in a single cell cycle: evidence for a replication licensing factor.
Article in The Journal of cell biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
69 citing papers in PubMed.
- Xenopus laevis Egg Extracts.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51.Nature communications · 2022Article
- E2F-dependent transcription determines replication capacity and S phase length.Nature communications · 2020Article
- Reconstituting Nuclear and Chromosome Dynamics UsingCold Spring Harbor protocols · 2019Article
- GSK-3 promotes S-phase entry and progression inDevelopment (Cambridge, England) · 2018Article
- The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines.Cell chemical biology · 2017Article
- Mechanisms and regulation of DNA replication initiation in eukaryotes.Critical reviews in biochemistry and molecular biology · 2017Review
- Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C. elegans Embryos.Cell reports · 2015Article
- Chromatin immunoprecipitation to detect DNA replication and repair factors.Methods in molecular biology (Clifton, N.J.) · 2015Article
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- Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis.Nature communications · 2013Article
- Mechanisms for initiating cellular DNA replication.Annual review of biochemistry · 2013Review
- Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote.Biology of reproduction · 2012Article
- Preparation and use of Xenopus egg extracts to study DNA replication and chromatin associated proteins.Methods (San Diego, Calif.) · 2012Article
- Identification of novel microRNAs in Xenopus laevis metaphase II arrested eggs.Genesis (New York, N.Y. : 2000) · 2012Article
- Mammalian sperm chromatin as a model for chromatin function in DNA degradation and DNA replication.Systems biology in reproductive medicine · 2011Review
- Sororin cooperates with the acetyltransferase Eco2 to ensure DNA replication-dependent sister chromatid cohesion.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Timing is everything: cell cycle control of Rad52.Cell division · 2010Article
- Asynchronous DNA replication and origin licensing in the mouse one-cell embryo.Journal of cellular biochemistry · 2009Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Xenopus egg extracts treated with the protein kinase inhibitor 6-dimethylaminopurine (6-DMAP) are unable to support the initiation of DNA replication. Nuclei assembled in 6-DMAP extracts behave as though they are in G2, and will not undergo another round of DNA replication until passage through mitosis. 6-DMAP extracts are functionally devoid of a replication factor that modifies chromatin in early G1 before nuclear envelope assembly, but which is itself incapable of crossing the nuclear envelope. This chromatin modification is capable of supporting only a single round of semiconservative replication. The behavior of this replication factor is sufficient to explain why eukaryotic DNA is replicated once and only once in each cell cycle, and conforms to the previous model of a Replication Licensing Factor. Cell cycle analysis shows that this putative Licensing Factor is inactive during metaphase, but becomes rapidly activated on exit from metaphase when it can modify chromatin before nuclear envelope assembly is complete.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.