ArticleThe Journal of cell biology1993
Molecular characterization of mammalian cylicin, a basic protein of the sperm head cytoskeleton.
Article in The Journal of cell biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 81 citations in OpenAlex.
- Perinuclear theca protein FNDC8 interacts with CCIN and ACTL7A to ensure proper sperm head shaping during spermiogenesis.Zoological research · 2025Article
- Novel CYLC1 variants are associated with male infertility due to sperm head deformity.Journal of assisted reproduction and genetics · 2025Article
- The Ultrastructure and Composition of Bovine Spermatozoa.Advances in anatomy, embryology, and cell biology · 2025Review
- Disruption ineLife · 2024Article
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- Identification of a novel deletion mutation inMolecular cytogenetics · 2020Article
- Proteomic alterations underlie an association with teratozoospermia in obese mice sperm.Reproductive biology and endocrinology : RB&E · 2019Article
- New Genes and Functional Innovation in Mammals.Genome biology and evolution · 2017Article
- Identification of microtubule growth deceleration and its regulation by conserved and novel proteins.Molecular biology of the cell · 2016Article
- Non-synonymous mutations mapped to chromosome X associated with andrological and growth traits in beef cattle.BMC genomics · 2015Article
- Gene expression profiles of prohibitin in testes of Octopus tankahkeei (ot-phb) revealing its possible role during spermiogenesis.Molecular biology reports · 2012Article
- Mechanisms underlying the micron-scale segregation of sterols and GM1 in live mammalian sperm.Journal of cellular physiology · 2009Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cytoskeletal calyx structure surrounding part of the nucleus of the mammalian sperm head contains two major kinds of basic proteins, i.e., the approximately 60-kD calicin and a group of very basic (IEP > pH 10) polypeptides ranging in size from approximately 58 to approximately 100 kD ("multiple band proteins," MBPs). We have produced MBP-specific mAbs and have isolated a bovine and a human cDNA clone encoding one of these proteins, termed "cylicin" (from the Greek word c eta kv lambda l zeta for cup or beaker). Bovine cylicin I of a calculated molecular weight of 74,788 contains a high proportion (29%) of positively charged amino acids, resulting in an IEP of 10.55, numerous KKD tripeptides, and is characterized by an organization of the central part of the molecule in nine repeating units of maximally 41 amino acids each of which according to prediction analysis should tend to form an alpha helix. The identity of the polypeptide has been proven by direct amino acid sequencing of > 14 different fragments and by experiments using antibodies raised against a partial cDNA-derived protein segment produced in E. coli. By Northern blot analysis we have identified the 2.4-kb cylicin I mRNA only in testis. The unusual cytoskeletal protein cylicin is compared with other proteins and its possible architectural role during spermiogenesis is discussed.
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