ArticleMolecular and cellular biochemistry1993
Induction of N-acetylglucosaminyltransferase V by elevated expression of activated or proto-Ha-ras oncogenes.
Article in Molecular and cellular biochemistry, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 52 citations in OpenAlex.
- Aberrant N-glycosylation in cancer: MGAT5 and β1,6-GlcNAc branched N-glycans as critical regulators of tumor development and progression.Cellular oncology (Dordrecht, Netherlands) · 2023Review
- Role of keratan sulfate expression in human pancreatic cancer malignancy.Scientific reports · 2019Article
- Glycans as Regulatory Elements of the Insulin/IGF System: Impact in Cancer Progression.International journal of molecular sciences · 2017Review
- Review
- The role of N-glycans in colorectal cancer progression: potential biomarkers and therapeutic applications.Oncotarget · 2016Review
- Protein glycosylation in cancer.Annual review of pathology · 2015Review
- Enhanced expression of the β4-galactosyltransferase 2 gene impairs mammalian tumor growth.Cancer gene therapy · 2014Article
- Lectins from the Red Marine Algal Species Bryothamnion seaforthii and Bryothamnion triquetrum as Tools to Differentiate Human Colon Carcinoma Cells.Advances in pharmacological sciences · 2009Article
- Effect of all trans retinoic acid on lysosomal alpha-D-mannosidase activity in HL-60 cell: correlation with HL-60 cells differentiation.Molecular and cellular biochemistry · 2008Article
- GnT-V, macrophage and cancer metastasis: a common link.Clinical & experimental metastasis · 2003Review
- N-linked oligosaccharides and metastatic propensity in in vivo selected mouse mammary adenocarcinoma cells.Clinical & experimental metastasis · 1999Article
- Regulation of N-acetylglucosaminyltransferase V and Asn-linked oligosaccharide beta(1,6) branching by a growth factor signaling pathway and effects on cell adhesion and metastatic potential.Glycoconjugate journal · 1997Review
- Reduced contact-inhibition and substratum adhesion in epithelial cells expressing GlcNAc-transferase V.The Journal of cell biology · 1995Article
- Tumor cell surface beta 1-6 branched oligosaccharides and lung metastasis.Clinical & experimental metastasis · 1994Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Viral infection of cultured cells with transforming viruses causes an increase in cell-surface N-linked beta 1-6 (GlcNAc beta 1-6Man) branching of complex-type oligosaccharides. Similar observations have been made after transfection of cells with activated oncogenes, which is associated with an induction of tumorigenic and metastatic properties. In this study, the effects of transfection of both activated and proto-Ha-ras oncogenes into NIH3T3 cells were analyzed. The results showed that, in comparison with NIH3T3 cells, both ras transfectants have increased sensitivity to the cytotoxic action of L-PHA. An increase in beta 1-6 branching and an increased level of N-acetylglucosaminyltransferase V (GlcNAc-T V), the enzyme which initiates the beta 1-6 branching were also observed. The levels of GlcNAc-T I and beta 1-4 Gal-T remained unchanged in activated Ha-ras transfected NIH3T3 cells. These data suggest that a specific induction of GlcNAc-T V occurs after transfection with either the proto- or activated Ha-ras oncogenes, which is responsible for the increased beta 1-6 branching previously observed.
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