Trial reportThe Journal of clinical investigation1993
Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses.
Trial report in The Journal of clinical investigation, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 4 syntheses or guidelines pooled it, 472 citations in OpenAlex.
- Allergen immunotherapy in allergic respiratory diseases: from mechanisms to meta-analyses.Chest · 2012Pooled it
- Allergen injection immunotherapy for seasonal allergic rhinitis.The Cochrane database of systematic reviews · 2007Pooled it
- Sublingual immunotherapy in asthma and rhinoconjunctivitis; systematic review of paediatric literature.Archives of disease in childhood · 2004Pooled it
- Cytokine expression in allergic inflammation: systematic review of in vivo challenge studies.Mediators of inflammation · 2003Pooled it
- Intradermal grass pollen immunotherapy increases TThe Journal of allergy and clinical immunology · 2017Trial
- Immunological markers in allergic rhinitis patients treated with date palm immunotherapy.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Trial
- SQ-standardized house dust mite immunotherapy as an immunomodulatory treatment in patients with asthma.Allergy · 2011Trial
- Grass pollen immunotherapy for hayfever is associated with increases in local nasal but not peripheral Th1:Th2 cytokine ratios.Immunology · 2002Trial
- Nanomaterials Reshaping Tumor Metabolism: A New Frontier to Overcome T Cell Exhaustion.International journal of nanomedicine · 2026Review
- Current Landscape and Future Directions in Cancer Immunotherapy: Therapies, Trials, and Challenges.Cancers · 2025Review
- Identification of key genes and the pathophysiology associated with allergen-specific immunotherapy for allergic rhinitis.BMC immunology · 2023Article
- Immunohistochemical Analysis of Postburn Scars following Treatment Using Dermal Substitutes.Analytical cellular pathology (Amsterdam) · 2022Article
- Article
- The Role of Regulatory T Cells in Epicutaneous Immunotherapy for Food Allergy.Frontiers in immunology · 2021Review
- Modulation of CRTh2 expression on allergen-specific T cells following peptide immunotherapy.Allergy · 2019Article
- Interleukin-31, Interleukin-31RA, and OSMR Expression Levels in Post-burn Hypertrophic Scars.Journal of pathology and translational medicine · 2018Article
- Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis.Allergy, asthma & immunology research · 2018Review
- Oral immunotherapy with omalizumab reverses the Th2 cell-like programme of regulatory T cells and restores their function.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018Article
- Chinese Guideline on allergen immunotherapy for allergic rhinitis.Journal of thoracic disease · 2017Review
- Immunotherapeutic efficacy of liposome-encapsulated refined allergen vaccines against Dermatophagoides pteronyssinus allergy.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have studied the influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. In a double-blind, placebo-controlled trial of immunotherapy in 40 adult hay fever sufferers, clinical improvement was accompanied by a decrease in the size of the late-phase skin response. When the immunotherapy-treated group was compared with the placebo group, analysis of skin biopsies obtained 24 h after intradermal allergen revealed a significant reduction in the number of infiltrating CD3+ (P = 0.04) and CD4+ (P = 0.009) cells and a trend for a decrease in EG2+ eosinophils (P = 0.08). Treatment did not influence allergen-induced recruitment of CD8+ cells, neutrophils, or macrophages. Unexpected increases in expression of CD25 (P = 0.006) and HLA-DR (P = 0.007) were observed in the actively treated group. In situ hybridization using a panel of riboprobes demonstrated "TH2-type" (IL-4, IL-5) cytokine mRNA responses in both groups of patients. In contrast, significant hybridization for IL-2 (8/16 patients, P = 0.02) and for interferon-gamma (6/16 patients, P = 0.04) was observed only in the actively treated group. These findings indicate that immunotherapy is associated with suppression of allergen-induced CD4+ T lymphocyte infiltration, but among the cells that are recruited, there is upregulation of CD25 and HLA-DR. At least in this model, immunotherapy does not appear to affect expression of TH2-pattern cytokines in response to allergen exposure, but expression of mRNA for Th1-type cytokines was enhanced in half of the patients. The results support the view that immunotherapy may possibly be working through induction of T cell tolerance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.