ArticleBreast cancer research and treatment1993
Candidate metastasis-associated genes of the rat 13762NF mammary adenocarcinoma.
Article in Breast cancer research and treatment, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 85 citations in OpenAlex.
- Mi-2β promotes immune evasion in melanoma by activating EZH2 methylation.Nature communications · 2024Article
- In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer.Nature communications · 2018Article
- [Regulation Mechanism of MTA3 in the Apoptosis of NSCLC Cells].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2015Article
- Structure and function insights into the NuRD chromatin remodeling complex.Cellular and molecular life sciences : CMLS · 2015Review
- Article
- Analysis of MAT3 gene expression in NSCLC.Diagnostic pathology · 2013Article
- eEF1A2 promotes cell migration, invasion and metastasis in pancreatic cancer by upregulating MMP-9 expression through Akt activation.Clinical & experimental metastasis · 2013Article
- Overexpression of MTA3 Correlates with Tumor Progression in Non-Small Cell Lung Cancer.PloS one · 2013Article
- Cancer biology and NuRD: a multifaceted chromatin remodelling complex.Nature reviews. Cancer · 2011Review
- Biomarkers of metastatic potential in cultured adenocarcinoma clones.Clinical & experimental metastasis · 2011Article
- Insights into association of the NuRD complex with FOG-1 from the crystal structure of an RbAp48·FOG-1 complex.The Journal of biological chemistry · 2011Article
- [Expression and significance of MTA2 in non-small cell lung cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2010Article
- Elongation Factor 1 alpha interacts with phospho-Akt in breast cancer cells and regulates their proliferation, survival and motility.Molecular cancer · 2009Article
- S100A4 overexpression proves to be independent marker for breast cancer progression.Cancer cell international · 2008Article
- Identification of Metastasis Associated Antigen 1 (MTA1) by Serological Screening of Prostate Cancer cDNA Libraries.The open biochemistry journal · 2008Article
- MTA family of transcriptional metaregulators in mammary gland morphogenesis and breast cancer.Journal of mammary gland biology and neoplasia · 2007Review
- The human Mi-2/NuRD complex and gene regulation.Oncogene · 2007Review
- eEF1A2 activates Akt and stimulates Akt-dependent actin remodeling, invasion and migration.Oncogene · 2007Article
- Hepatitis C virus NS4A inhibits cap-dependent and the viral IRES-mediated translation through interacting with eukaryotic elongation factor 1A.Journal of biomedical science · 2006Article
- Metastatic tumor antigen 3 is a direct corepressor of the Wnt4 pathway.Genes & development · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Differential hybridization was used to isolate genes potentially involved in the process of metastasis. Ten complementary DNAs (cDNAs) that were differentially expressed between a highly metastatic (MTLn3) and a nonmetastatic (MTC.4) line of the rat 13762NF mammary adenocarcinoma were isolated and sequenced. Examination of the EMBL/GenBank database revealed that one of the genes had a high degree of homology (98.8%) to annexin I (also known as calpactin II). Quantitative analysis of Northern blot hybridizations showed that the annexin I-like sequence was expressed 4- to 7-fold higher in MTLn3 than in MTC.4 cells. Steady state mRNA levels were also low in MTLn2, a cell line of low metastatic potential closely related to MTLn3, but were not related to metastatic potential in colon adenocarcinoma or melanoma cells. Two of the cDNAs (designated 8.11 and 10.14) were found to be novel. The expression of 10.14 mRNA (3.2 kb) was 4-fold higher in MTLn3 than in MTC.4 cells. Sequencing of the 10.14 cDNA (2.2 kb) revealed a putative open reading frame of 583 amino acids that was also novel. Expression of 8.11 mRNA (> 7 kb) inversely correlated with metastatic potential. Another differentially transcribed gene was highly homologous to ERK2 (extracellular signal related kinase 2), a mitogen-activated protein kinase (MAPK). Northern analysis of ERK2 expression revealed 3-fold higher amounts of a 1.3 kb mRNA in MTLn3 than in MTC.4 cells. Higher levels of ERK2 mRNA were generally seen in the more metastatic human colon but not in melanoma cell lines. We also corroborated the work of Taniguchi (Nucl Acids Res 19:6949, 1991) by independently identifying EF-1 alpha as a putative metastasis-associated gene.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.