ArticleBritish journal of cancer1993
Congenital abnormalities in children with cancer and their relatives: results from a case-control study (IRESCC).
Article in British journal of cancer, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Pooled it
- Prevalence of congenital heart defects in neuroblastoma patients: a cohort study and systematic review of literature.European journal of pediatrics · 2009Pooled it
- Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study.Pediatric blood & cancer · 2026Article
- Role of non-chromosomal birth defects on the risk of developing childhood Hodgkin lymphoma: A Children's Oncology Group study.Pediatric blood & cancer · 2024Article
- Article
- Risk of thyroid neoplasms in patients with 22q11.2 deletion and DiGeorge-like syndromes: an insight for follow-up.Frontiers in endocrinology · 2023Article
- Childhood cancer in children with congenital anomalies in Oklahoma, 1997 to 2009.Birth defects research. Part A, Clinical and molecular teratology · 2016Article
- Family history of cancer and non-malignant diseases and risk of childhood acute lymphoblastic leukemia: a Children's Oncology Group Study.Cancer epidemiology · 2012Article
- Paediatric germ cell tumours and congenital abnormalities: a Children's Oncology Group study.British journal of cancer · 2009Article
- Congenital abnormalities and acute leukemia among children with Down syndrome: a Children's Oncology Group study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2008Article
- [Neonatal tumours and congenital malformations].Anales de pediatria (Barcelona, Spain : 2003) · 2008Article
- Hodgkin's lymphoma and infection: findings from a UK case-control study.British journal of cancer · 2007Article
- Cancer risk in persons with oral cleft--a population-based study of 8,093 cases.American journal of epidemiology · 2005Article
- Absence of leukaemic fusion gene transcripts in preterm infants exposed to diagnostic x rays.Archives of disease in childhood. Fetal and neonatal edition · 2003Article
- Childhood cancer and parental use of tobacco: findings from the inter-regional epidemiological study of childhood cancer (IRESCC).British journal of cancer · 2001Article
- Critical windows of exposure for children's health: cancer in human epidemiological studies and neoplasms in experimental animal models.Environmental health perspectives · 2000Review
- Associations between congenital malformations and childhood cancer. A register-based case-control study.British journal of cancer · 1998Article
- Congenital anomalies and childhood cancer in Great Britain.American journal of human genetics · 1997Article
- Genetics and epidemiology, congenital anomalies and cancer.American journal of human genetics · 1997Article
- Cancer and congenital abnormalities in Asian children: a population-based study from the West Midlands.British journal of cancer · 1995Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies have revealed an excess of malformations in children with certain malignancies. A few environmental causes have been identified which may damage the foetus and lead to malformation and cancer. However, most of the numerous recognised cancer/malformation syndromes are genetically determined. This report describes a case-control study of 555 newly diagnosed children with cancer and 1,110 matched controls, chosen from general practitioner lists (GP controls) and hospital admissions (H controls). Their parents were interviewed on topics of possible aetiological significance and medical records were checked to confirm reports at interview. The numbers of congenital malformations in the index and GP control children, and the relatives of the index children, the GP and H controls are described. There were more children with malformations among the cases (60/555) than among the GP controls (27/555), P < 0.001. The abnormalities in the cases included eight with specific chromosomal/genetic conditions (e.g. Down's syndrome, XY gonadal dysgenesis, Von Recklinghausen's neurofibromatosis, Goldenhar's syndrome) whereas only one GP control child had a chromosomal defect (P < 0.05). Five case children but no GP controls had neural tube defects; this is not statistically significant. No excess of malformations was found in the siblings of cases compared with GP and H control siblings. Case mothers had a small excess of malformations (22/555) compared with GP controls (8/555), P < 0.05. Among more distant relatives the results were difficult to interpret because of the relatively small numbers in the diagnostic subgroups and because of apparent under reporting in grandparents, but no striking differences were seen between case and control relatives. The excess of malformations found in children with cancer, compared with controls, without a similar excess of malformations in their close relatives may indicate that in some (perhaps very roughly one in 20) cases antenatal events may lead both to the malformation and the malignancy.
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