ArticleBritish journal of cancer1993
Glutathione S-transferase expression in benign and malignant ovarian tumours.
Article in British journal of cancer, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- Prognostic significance of several biomarkers in epithelial ovarian cancer: a meta-analysis of published studies.Journal of cancer research and clinical oncology · 2013Pooled it
- Synthesis and Anticancer Potential of New Hydroxamic Acid Derivatives as Chemotherapeutic Agents.Applied biochemistry and biotechnology · 2022Article
- Targeting Drug Chemo-Resistance in Cancer Using Natural Products.Biomedicines · 2021Review
- Glutathione in Ovarian Cancer: A Double-Edged Sword.International journal of molecular sciences · 2018Review
- On the Inhibition Mechanism of Glutathione Transferase P1 by Piperlongumine. Insight From Theory.Frontiers in chemistry · 2018Article
- Overcome Cancer Cell Drug Resistance Using Natural Products.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- Impact of obesity on ovotoxicity induced by 7,12-dimethylbenz[a]anthracene in mice.Biology of reproduction · 2014Article
- The role of the tumor stroma in ovarian cancer.Frontiers in oncology · 2014Review
- GSTPi-positive tumour microenvironment-associated fibroblasts are significantly associated with GSTPi-negative cancer cells in paired cases of primary invasive breast cancer and axillary lymph node metastases.British journal of cancer · 2011Article
- Pharmacogenomics of cisplatin-induced ototoxicity.Pharmacogenomics · 2011Review
- Developing central nervous system and vulnerability to platinum compounds.Chemotherapy research and practice · 2011Article
- Characterization of the molecular forms of glutathione S-transferase P1 in human gastric cancer cells (Kato III) and in normal human erythrocytes.The Biochemical journal · 2005Article
- Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.Genes & development · 2004Article
- Human osteosarcoma xenografts and their sensitivity to chemotherapy.Pathology oncology research : POR · 2004Article
- Overcoming drug resistance in ovarian carcinoma.Current oncology reports · 2001Review
- Expression of pi-class glutathione S-transferase: two populations of high grade prostatic intraepithelial neoplasia with different relations to carcinoma.Molecular pathology : MP · 2000Article
- Immunohistochemical expression of pi class glutathione S-transferase in the basal cell layer of benign prostate tissue following chronic treatment with finasteride.Journal of clinical pathology · 1999Article
- Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Endogenous antioxidant enzymes and glutathione S-transferase in protection of mesothelioma cells against hydrogen peroxide and epirubicin toxicity.British journal of cancer · 1998Article
- P-glycoprotein-mediated multidrug resistance and lymphokine-activated killer cell susceptibility in ovarian carcinoma.Journal of clinical immunology · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutathione S-transferase sub-types alpha, mu and pi were assessed by immunocytochemistry in 109 biopsies of ovarian tissue, comprising malignant epithelial tissue in 86 cases and tissue of ovarian origin considered to be normal in 23. Glutathione S-transferase pi was the most prevalent, being present in all except one malignant epithelium studied and 83% of non-malignant tissue. There were no significant differences in the overall distribution of positive staining for alpha, mu and pi in the malignant and non-malignant biopsies, although the intensity of staining was greater in the malignant epithelium. Stromal staining was in general more pronounced in the malignant biopsies, and this was particularly prominent in the case of the alpha sub-type. Positive staining was seen more frequently in the less well-differentiated tumours, and a diffuse cytoplasmic pattern was the most common observation in tumours of moderate and poor differentiation. There was no significant association between survival and the presence or absence of sub-type staining of alpha and mu sub-type. For the sub-type pi, patient survival was found to correlate with the intensity of staining (on a 0-(+++) scale). Those patients showing resistance to cytotoxic chemotherapy were found to have a higher intensity of staining for GST pi than responding patients.
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Registered trials
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