ReviewApplied biochemistry and biotechnology
Cellular and metabolic engineering. An overview.
Review in Applied biochemistry and biotechnology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Removing the Bottleneck: Introducing cMatch - A Lightweight Tool for Construct-Matching in Synthetic Biology.Frontiers in bioengineering and biotechnology · 2021Article
- Improving Escherichia coli membrane integrity and fatty acid production by expression tuning of FadL and OmpF.Microbial cell factories · 2017Article
- Modification of glucose import capacity in Escherichia coli: physiologic consequences and utility for improving DNA vaccine production.Microbial cell factories · 2013Article
- The genome-scale metabolic network analysis of Zymomonas mobilis ZM4 explains physiological features and suggests ethanol and succinic acid production strategies.Microbial cell factories · 2010Article
- Identifying quantitative operation principles in metabolic pathways: a systematic method for searching feasible enzyme activity patterns leading to cellular adaptive responses.BMC bioinformatics · 2009Article
- Yeast cell factories for fine chemical and API production.Microbial cell factories · 2008Article
- Improvement of Escherichia coli production strains by modification of the phosphoenolpyruvate:sugar phosphotransferase system.Microbial cell factories · 2005Article
- Metabolic engineering of Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 2000Review
- Production of succinic acid through overexpression of NAD(+)-dependent malic enzyme in an Escherichia coli mutant.Applied and environmental microbiology · 1997Article
- Construction of a starch-utilizing yeast by cell surface engineering.Applied and environmental microbiology · 1997Article
- Metabolic control analysis of biochemical pathways based on a thermokinetic description of reaction rates.The Biochemical journal · 1997Article
- Flow cytometry and cell sorting of heterogeneous microbial populations: the importance of single-cell analyses.Microbiological reviews · 1996Review
- Engineering of Escherichia coli central metabolism for aromatic metabolite production with near theoretical yield.Applied and environmental microbiology · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic engineering is defined as the purposeful modification of intermediary metabolism using recombinant DNA techniques. Cellular engineering, a more inclusive term, is defined as the purposeful modification of cell properties using the same techniques. Examples of cellular and metabolic engineering are divided into five categories: 1. Improved production of chemicals already produced by the host organism; 2. Extended substrate range for growth and product formation; 3. Addition of new catabolic activities for degradation of toxic chemicals; 4. Production of chemicals new to the host organism; and 5. Modification of cell properties. Over 100 examples of cellular and metabolic engineering are summarized. Several molecular biological, analytical chemistry, and mathematical and computational tools of relevance to cellular and metabolic engineering are reviewed. The importance of host selection and gene selection is emphasized. Finally, some future directions and emerging areas are presented.
Indexed as
Identifiers
8346901What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.