ArticleAnnals of surgery1993
Developmental expression of the neurotensin gene in the rat liver.
Article in Annals of surgery, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 13 citations in OpenAlex.
- Biased signaling at NTSR1 differentially regulates inhibitory synaptic transmission in the extended amygdala and suppresses motivated feeding in mice.bioRxiv : the preprint server for biology · 2026Article
- Fibrolamellar carcinoma: 2012 update.Scientifica · 2012Review
- Characterization of early developmental pattern of expression of neurotensin/neuromedin N gene in foregut and midgut.Digestive diseases and sciences · 1999Article
- Expression of the neurotensin gene in fetal human liver and fibrolamellar carcinoma.Annals of surgery · 1994Article
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
objectiveThis study determined whether the neurotensin gene is expressed during early development of the liver. SUMMARY BACKGROUND DATA: Neurotensin (NT), a gut tridecapeptide localized mainly to the distal small bowel and brain of adults, is an important hormone regulating gut motility, secretion and mucosal growth. Expression of NT peptide and the gene is found in fibrolamellar hepatocarcinomas, a variant of hepatocellular carcinoma, but not in the normal adult liver.
methodsNorthern and in situ hybridization techniques were used to determine expression of the neurotensin gene (NT/N) in the normal developing liver.
resultsNT/N is expressed in the fetal and early postnatal rat liver, but expression is repressed in the liver of the adult. In situ hybridization confirms the authors' Northern data and demonstrates a random distribution of NT/N expression in the fetal and 3-day postnatal liver.
conclusionsThe authors conclude from this study that NT/N is expressed during early development of the rat liver with subsequent repression in the adult. NT/N may be reexpressed with malignant transformation of the liver.
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