ArticleProceedings of the National Academy of Sciences of the United States of America1993
Rare scleroderma autoantibodies to the U11 small nuclear ribonucleoprotein and to the trimethylguanosine cap of U small nuclear RNAs.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Case-Based Immunology: B Cells and Systemic Sclerosis Interstitial Lung Disease.Arthritis & rheumatology (Hoboken, N.J.) · 2026Review
- Systemic Sclerosis-Specific Antibodies: Novel and Classical Biomarkers.Clinical reviews in allergy & immunology · 2023Article
- Anti-U11/U12 Antibodies as a Rare but Important Biomarker in Patients with Systemic Sclerosis: A Narrative Review.Diagnostics (Basel, Switzerland) · 2023Review
- Minor Intron Splicing from Basic Science to Disease.International journal of molecular sciences · 2021Review
- Pathogenic Roles of Autoantibodies and Aberrant Epigenetic Regulation of Immune and Connective Tissue Cells in the Tissue Fibrosis of Patients with Systemic Sclerosis.International journal of molecular sciences · 2020Review
- Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment.Journal of molecular biology · 2016Article
- Crystal structure of an RNA polymerase ribozyme in complex with an antibody fragment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Article
- Frequency of disease-associated and other nuclear autoantibodies in patients of the German Network for Systemic Scleroderma: correlation with characteristic clinical features.Arthritis research & therapy · 2011Article
- Anti-U11/U12 RNP antibodies in systemic sclerosis: a new serologic marker associated with pulmonary fibrosis.Arthritis and rheumatism · 2009Article
- Synthetic antibodies for specific recognition and crystallization of structured RNA.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.RNA (New York, N.Y.) · 2004Article
- The SMN complex is associated with snRNPs throughout their cytoplasmic assembly pathway.Molecular and cellular biology · 2002Article
- AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes.Molecular and cellular biology · 1999Review
- SR protein splicing factors interact with the Rous sarcoma virus negative regulator of splicing element.Journal of virology · 1996Article
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2 authors.
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Abstract
We have identified a scleroderma serum (Ru) with a previously undescribed specificity to protein components of the U11 small nuclear ribonucleoprotein particle (snRNP), a low-abundance member of the Sm class of U RNPs. The U11 RNP can be specifically immunoprecipitated from sonicated HeLa cells with Ru serum. In nuclear extracts, a fraction of the U11 particle is found complexed to the U12 RNP, an even lower abundance Sm snRNP. In glycerol gradient fractions, Ru serum identifies a 65-kDa protein that cosediments with the U11-U12 complex and is shifted upon targeted degradation of the U12 RNA. The 65-kDa protein therefore appears to be a component of the U11-U12 snRNP complex, whereas another Ru-reactive (140 kDa) protein may be associated with the free U11 RNP. The Ru serum also contains autoantibodies directed against the trimethylguanosine cap of U RNAs. This rare specificity has been described previously in only three other scleroderma patients.
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