ArticleProceedings of the National Academy of Sciences of the United States of America1993
cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
57 citing papers in PubMed, 223 citations in OpenAlex.
- Targeting the FSH/FSHR axis in ovarian cancer: advanced treatment using nanotechnology and immunotherapy.Frontiers in endocrinology · 2024Review
- Proprotein Convertases and the Complement System.Frontiers in immunology · 2022Review
- Overview of follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells.International journal of biological sciences · 2022Review
- Strategies for the Identification of Bioactive Neuropeptides in Vertebrates.Frontiers in neuroscience · 2019Review
- Follicle-Stimulating Hormone Receptor (FSHR): A Promising Tool in Oncology?Molecular diagnosis & therapy · 2016Review
- Validation of the manufacturing process used to produce long-acting recombinant factor IX Fc fusion protein.Haemophilia : the official journal of the World Federation of Hemophilia · 2014Article
- Clinical utility and patient perspectives on the use of extended half-life rFIXFc in the management of hemophilia B.Patient preference and adherence · 2014Review
- Relative expression of proprotein convertases in rat ovaries during pregnancy.Journal of ovarian research · 2013Article
- Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.American journal of physiology. Lung cellular and molecular physiology · 2013Article
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- The biology and therapeutic targeting of the proprotein convertases.Nature reviews. Drug discovery · 2012Review
- Coagulation Factor IX for Hemophilia B Therapy.Acta naturae · 2012Article
- Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy.Journal of molecular medicine (Berlin, Germany) · 2011Article
- Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.The Journal of biological chemistry · 2011Article
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- Article
- Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels.Circulation. Cardiovascular genetics · 2009Article
- The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model.Molecular cancer · 2009Article
- In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- The cell-specific pattern of cholecystokinin peptides in endocrine cells versus neurons is governed by the expression of prohormone convertases 1/3, 2, and 5/6.Endocrinology · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By using reverse transcriptase/PCR and oligonucleotide sequences derived from conserved segments (including the conserved RRGDL sequence) of the known proprotein convertases (PCs) PC1, PC2, furin, and PC4, we identified a subtilisin/kexin-like PC called PC5 in both mouse and rat tissues. The composite structure (2.85 kb) was deduced from the analysis of the reverse transcription/PCR products combined with the sequence from a clone isolated from a cDNA library made from corticotropin-activated mouse adrenocortical Y1 cells. The deduced cDNA structures of mouse PC5 and rat PC5 showed that the closest homologue is PACE4. Furthermore, like furin, Drosophila melanogaster (d) dfurin2, and PACE4, PC5 shows the presence of a C-terminal Cys-rich domain containing either 5 (PC5 and PACE4) or 10 (dfurin2) repeats of the consensus motif Cys-Xaa2-Cys-Xaa3-Cys-Xaa(5-7)-Cys-Xaa2-Cys-Xaa (8-15)-Cys-Xaa3-Cys-Xaa(9-16). The richest sources of rat PC5 mRNA (3.8 kb) are the adrenal and gut, but it can also be detected in many endocrine and nonendocrine tissues. Corticotropin-stimulated adrenocortical Y1 cells showed an increased expression of PC5 mRNA, suggesting an upregulation by cAMP. In situ hybridization of rat brain sections demonstrated a unique distribution of PC5 compared to PC1, PC2, and furin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.