ArticleProceedings of the National Academy of Sciences of the United States of America1993
Differential organ-specific expression of three poly(A)-binding-protein genes from Arabidopsis thaliana.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 82 citations in OpenAlex.
- Genome-wide investigation of the LARP gene family: focus on functional identification and transcriptome profiling of ZmLARP6c1 in maize pollen.BMC plant biology · 2024Article
- Characterization of ALBA Family Expression and Localization inInternational journal of molecular sciences · 2021Article
- Comparative proteomics of the two T. brucei PABPs suggests that PABP2 controls bulk mRNA.PLoS neglected tropical diseases · 2018Article
- Class II members of the poly(A) binding protein family exhibit distinct functions during Arabidopsis growth and development.Translation (Austin, Tex.) · 2017Article
- Phylogenetic analysis reveals dynamic evolution of the poly(A)-binding protein gene family in plants.BMC evolutionary biology · 2014Article
- Article
- The ABORTED MICROSPORES regulatory network is required for postmeiotic male reproductive development in Arabidopsis thaliana.The Plant cell · 2010Article
- Functional analysis of the Arabidopsis thaliana poly(A) binding protein PAB5 gene promoter in Nicotiana tabacum.Plant cell reports · 2008Article
- Nitrogen-dependent posttranscriptional regulation of the ammonium transporter AtAMT1;1.Plant physiology · 2007Article
- The 73 kD subunit of the cleavage and polyadenylation specificity factor (CPSF) complex affects reproductive development in Arabidopsis.Plant molecular biology · 2006Article
- Four distinct classes of proteins as interaction partners of the PABC domain of Arabidopsis thaliana Poly(A)-binding proteins.Molecular genetics and genomics : MGG · 2005Article
- Posttranscriptional control of plant development.Current opinion in plant biology · 2004Review
- Identification and characterization of proteins that interact with the carboxy terminus of poly(A)-binding protein and inhibit translation in vitro.Plant molecular biology · 2004Article
- Comparative analysis of the Arabidopsis pollen transcriptome.Plant physiology · 2003Article
- Article
- Genome analysis: RNA recognition motif (RRM) and K homology (KH) domain RNA-binding proteins from the flowering plant Arabidopsis thaliana.Nucleic acids research · 2002Article
- Isovariant dynamics expand and buffer the responses of complex systems: the diverse plant actin gene family.The Plant cell · 1999Review
- Article
- A poly(A) binding protein functions in the chloroplast as a message-specific translation factor.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Control of mRNA stability in higher plants.Plant molecular biology · 1996Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Poly(A)-binding protein (PABP) is considered an essential component of a eukaryotic cell; deletion of the PABP-coding gene in yeast leads to a lethal phenotype. PABP is implicated in numerous aspects of posttranscriptional regulation, including mRNA turnover and translational initiation. A nested set of degenerate PCR primers designed from regions conserved among yeast, Xenopus, and human PABP sequences was used to amplify genomic DNA fragments from Arabidopsis thaliana. Hybridization screening of genomic and cDNA libraries with a genomic PCR probe led to the isolation of three diverse Arabidopsis genes encoding PABPs, PAB1, PAB3, and PAB5. All three sequences contain the expected four RNA-recognition motifs. Sequence diversity between these genes equals or exceeds the diversity among animal and fungal sequences. One of the genes, PAB5, and its cDNA were completely sequenced. Its open reading frame encodes a 73.2-kDa protein containing a number of amino acid motifs characteristic of PABPs from different species. Moreover, in vitro synthesized PAB5 protein bound to poly(A)-Sepharose with high specificity. All three genes isolated showed organ-specific patterns of expression. PAB5 and PAB3 RNAs were detected only in floral organs, with the highest level of expression in immature flowers. PAB1 RNA was observed predominantly in roots, was less abundant in immature flowers, and was not detected in any other organ examined (stems, leaves, mature flowers, siliques). This suggests a potentially unique role for PABPs in organ-specific posttranscriptional regulation in plants.
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