ArticleProceedings of the National Academy of Sciences of the United States of America1993
VH gene organization in a relict species, the coelacanth Latimeria chalumnae: evolutionary implications.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 29 citations in OpenAlex.
- Genome complexity in the coelacanth is reflected in its adaptive immune system.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2014Article
- Lineage-restricted retention of a primitive immunoglobulin heavy chain isotype within the Dipnoi reveals an evolutionary paradox.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Primordial emergence of the recombination activating gene 1 (RAG1): sequence of the complete shark gene indicates homology to microbial integrases.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Evolution of immunoglobulin heavy chain variable region genes: a VH family can last for 150-200 million years or longer.Immunogenetics · 1995Article
- Major histocompatibility complex class I genes of the coelacanth Latimeria chalumnae.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- The immunoglobulin repertoire of the rainbow trout (Oncorhynchus mykiss): definition of nine Igh-V families.Immunogenetics · 1994Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
The living coelacanth Latimeria chalumnae is a relict species whose higher-level phylogenetic relationships have not been resolved clearly by traditional systematic approaches. Previous studies show that major differences in immunoglobulin gene structure and organization typify different phylogenetic lineages. To date, mammalian-, avian-, and elasmobranch-type gene organizations have been identified in representatives of these different phylads. A fourth form or organization is found in Latimeria, which possesses immunoglobulin heavy-chain variable region (VH) elements separated by approximately 190 nucleotides from diversity (D) elements. Adjacency of VH and D elements is characteristic of the elasmobranch "clustered" arrangement, although many other features of coelacanth VH gene organization and structure are more similar to those of bony fishes and tetrapods. These observations strongly support a phylogenetic hypothesis in which Latimeria occupies a sister-group relationship with teleosts and tetrapods.
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