ArticleProceedings of the National Academy of Sciences of the United States of America1993
At day 8-8.5 of mouse development the yolk sac, not the embryo proper, has lymphoid precursor potential in vivo and in vitro.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The ins and outs of innate and adaptive type 2 immunity.Immunity · 2023Review
- Epidermal γδ T cells originate from yolk sac hematopoiesis and clonally self-renew in the adult.The Journal of experimental medicine · 2018Article
- Deconvoluting the ontogeny of hematopoietic stem cells.Cellular and molecular life sciences : CMLS · 2014Review
- Erythroid development in the mammalian embryo.Blood cells, molecules & diseases · 2013Review
- Article
- Hemato-lymphoid in vivo reconstitution potential of subpopulations derived from in vitro differentiated embryonic stem cells.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- In vivo repopulating hematopoietic stem cells are present in the murine yolk sac at day 9.0 postcoitus.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Primitive lymphohematopoietic precursor cell lines generated in culture from day 7 early-mid-primitive streak stage mouse embryo.The EMBO journal · 1996Article
- In vitro and in vivo differentiation into B cells, T cells, and myeloid cells of primitive yolk sac hematopoietic precursor cells expanded > 100-fold by coculture with a clonal yolk sac endothelial cell line.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- HEMCAM, an adhesion molecule expressed by c-kit+ hemopoietic progenitors.The Journal of cell biology · 1996Article
- Development of Valpha4+ NK T cells in the early stages of embryogenesis.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Emergence of multipotent hemopoietic cells in the yolk sac and paraaortic splanchnopleura in mouse embryos, beginning at 8.5 days postcoitus.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- In vitro generation of lymphoid precursors from embryonic stem cells.The EMBO journal · 1994Article
- Genetic analysis of transcription factors implicated in B lymphocyte development.Immunologic research · 1994Review
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2 authors.
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Abstract
We have studied both in vitro and in vivo the formation of lymphocyte progenitors before blood circulation (day 9 of gestation) has started in the mouse embryo, and we have determined the tissue where this occurs. The results demonstrate that the yolk sac of embryos at day 8 and day 8.5 of gestation contains precursor cells that can give rise, in vivo and in vitro, to mature T and B lymphocytes. No lymphoid precursors were found in the embryo proper at this stage of mouse development. The yolk sac cells with lymphocyte precursor potential are most likely multipotent stem cells rather than cell-lineage-determined T- and/or B-lymphocyte progenitors. The defined in vitro assays described here that support differentiation of yolk sac stem cells along the T- or B-lymphocyte pathways also may now facilitate the study of the molecular events leading to cell-lineage commitment of lymphocyte progenitors in the mouse embryo.
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