ArticleProceedings of the National Academy of Sciences of the United States of America1993
Differentiation and characterization of B-cell precursors detected in the yolk sac and embryo body of embryos beginning at the 10- to 12-somite stage.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 102 citations in OpenAlex.
- Hematopoietic Stem Cell Development in Mammalian Embryos.Advances in experimental medicine and biology · 2023Review
- Discovery and Function of B-Cell IgD Low (BDJournal of molecular biology · 2021Review
- Restricted intra-embryonic origin of bona fide hematopoietic stem cells in the chicken.Development (Cambridge, England) · 2017Article
- Erythroid development in the mammalian embryo.Blood cells, molecules & diseases · 2013Review
- B-1 B cell development in the fetus and adult.Immunity · 2012Review
- Stem cell emergence and hemopoietic activity are incompatible in mouse intraembryonic sites.The Journal of experimental medicine · 1999Article
- The SCL gene specifies haemangioblast development from early mesoderm.The EMBO journal · 1998Article
- Development of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor beta chain-independent pathway.The Journal of experimental medicine · 1995Article
- Emergence of multipotent hemopoietic cells in the yolk sac and paraaortic splanchnopleura in mouse embryos, beginning at 8.5 days postcoitus.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- In vitro generation of lymphoid precursors from embryonic stem cells.The EMBO journal · 1994Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The embryonic sites in which progenitors of the hematopoietic lineages first emerge are ideal regions to characterize both the cells and environment needed to initiate blood cell development. For a number of years both the murine yolk sac and embryo have been recognized to contain progenitors of B lymphocytes. However, clonal, quantitative in vitro assays, which allow precise observation of precursors and their progeny, have been lacking. Moreover, the site of origin of the initial events remains controversial. In this report we document the presence of B-cell progenitors in yolk sac and embryonic tissue obtained from mouse fetuses beginning at the 10-somite stage, day 8.5. We determine the frequency, cell-surface phenotype, and growth properties of these progenitors. We show that these cells can differentiate into immunoglobulin-secreting cells and that the progeny derived from single progenitors are diverse with respect to immunoglobulin heavy-chain allotype expression, diversity-joining region use, and heavy-chain variable-region utilization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.