Evidence map›Paper›PMID 8341642›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America1993

Direct selection of antibodies that coordinate metals from semisynthetic combinatorial libraries.

C F Barbas, J S Rosenblum, R A Lerner

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 101 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Article
  6. Review
  7. Article
  8. A rationally designed agonist antibody fragment that functionally mimics thrombopoietin.Proceedings of the National Academy of Sciences of the United States of America · 2006
    Article
  9. Interfacial metal and antibody recognition.Proceedings of the National Academy of Sciences of the United States of America · 2005
    Article
  10. A cofactor approach to copper-dependent catalytic antibodies.Proceedings of the National Academy of Sciences of the United States of America · 2002
    Article
  11. Article
  12. Article
  13. Sequestration of zinc oxide by fimbrial designer chelators.Applied and environmental microbiology · 2000
    Article
  14. Generation of recombinant antibodies.Molecular biotechnology · 1999
    Review
  15. Article
  16. Review
  17. Article
  18. Synthetic human antibodies.Nature medicine · 1995
    Review
  19. Human autoantibody recognition of DNA.Proceedings of the National Academy of Sciences of the United States of America · 1995
    Article
  20. Direct selection for a catalytic mechanism from combinatorial antibody libraries.Proceedings of the National Academy of Sciences of the United States of America · 1994
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

C F BarbasDepartment of Chemistry, Scripps Research Institute, La Jolla, CA 92037.
J S Rosenblum
R A Lerner
Scripps Research Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An iterative strategy for the selection of catalytic metalloantibodies is described. The first stage of this strategy is validated by the selection of semisynthetic antibodies that coordinate a variety of different metal ions and the metal oxide magnetite. These results have implications not only for the development of catalytic metalloantibodies but also for the development of reagents for magnetic resonance imaging, delivery of radioisotopes, and purification of recombinant proteins.

Indexed as

Selection, GeneticAmino Acid SequenceAntibodies, CatalyticAntibody SpecificityBase SequenceCopperFerrosoferric OxideGene LibraryGenes, ImmunoglobulinHumansImmunoglobulin Fab FragmentsIronMetalsModels, MolecularMolecular Sequence DataOxidesAntibodies, CatalyticCopperFerrosoferric OxideImmunoglobulin Fab FragmentsIronMetalsOxides

Identifiers

PMID8341642
PMCPMC46936
OpenAlexW2051604859

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.