ArticleNucleic acids research1993
A novel Brn3-like POU transcription factor expressed in subsets of rat sensory and spinal cord neurons.
Article in Nucleic acids research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 108 citations in OpenAlex.
- A gene regulatory network for specification and morphogenesis of a Mauthner Cell homolog in non-vertebrate chordates.Developmental biology · 2025Article
- Brn3a controls the soma localization and axonal extension patterns of developing spinal dorsal horn neurons.PloS one · 2023Article
- Article
- Diversity among POU transcription factors in chromatin recognition and cell fate reprogramming.Cellular and molecular life sciences : CMLS · 2018Review
- Transcription Factor Brn-3b Overexpression Enhances Neurite Outgrowth in PC12 Cells Under Condition of Hypoxia.Cellular and molecular neurobiology · 2015Article
- Expression of P450c17 in the human fetal nervous system.Endocrinology · 2012Article
- Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord.Developmental biology · 2012Article
- Article
- Caprin-1 is a target of the deafness gene Pou4f3 and is recruited to stress granules in cochlear hair cells in response to ototoxic damage.Journal of cell science · 2011Article
- Direct inhibition of the DNA-binding activity of POU transcription factors Pit-1 and Brn-3 by selective binding of a phenyl-furan-benzimidazole dication.Nucleic acids research · 2008Article
- Missense mutations in POU4F3 cause autosomal dominant hearing impairment DFNA15 and affect subcellular localization and DNA binding.Human mutation · 2008Article
- Transcription factor interactions and chromatin modifications associated with p53-mediated, developmental repression of the alpha-fetoprotein gene.Molecular and cellular biology · 2005Article
- Cloning and initial characterization of an alternatively spliced transcript encoded by the bovine herpes virus 1 latency-related gene.Journal of neurovirology · 2003Article
- The DFNA15 deafness mutation affects POU4F3 protein stability, localization, and transcriptional activity.Molecular and cellular biology · 2003Article
- Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor.Oncogene · 2003Article
- The Brn-3b POU family transcription factor represses expression of the BRCA-1 anti-oncogene in breast cancer cells.Oncogene · 1999Article
- The N-terminal domain unique to the long form of the Brn-3a transcription factor is essential to protect neuronal cells from apoptosis and for the activation of Bbcl-2 gene expression.Nucleic acids research · 1998Article
- Auditory hair cell precursors immortalized from the mammalian inner ear.Proceedings. Biological sciences · 1998Article
- Neuronal expression of the 5HT3 serotonin receptor gene requires nuclear factor 1 complexes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element.Molecular and cellular biology · 1998Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brn3a and Brn3b are mammalian members of the POU class of transcription factors. They are closely related to each other and to Unc86, which determines the normal development of certain cells, including mechanoreceptive sensory neurons in Caenorhabditis elegans. We screened a rat dorsal root ganglion (DRG) cDNA library at moderate stringency with a Brn3a POU-domain probe and identified a novel transcript encoding a POU protein that we have named Brn3c. Brn3c closely resembles Brn3a and Brn3b in its POU-domain and thus helps define a family of Unc86-related mammalian POU factors. Both Brn3a and Brn3c are expressed only in the central and peripheral nervous systems. In the neonatal rat, northern blots revealed a 3.6 kb Brn3a transcript in DRG, spinal cord and hindbrain, and a 2.6 kb Brn3c transcript in DRG and spinal cord. In situ hybridization showed that most DRG neurons express Brn3a whereas only a small subset of neurons expresses Brn3c. In the spinal cord, Brn3a is expressed by many dorsal horn neurons. In contrast, Brn3c is expressed by a very small number of cells in laminae 4/5 of the dorsal horn. These data suggest that Brn3-related POU factors may be involved in the development or function of particular subclasses of sensory and spinal cord neurons.
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