ArticleMolecular & general genetics : MGG1993
A nucleotide substitution in one of the beta-tubulin genes of Trichoderma viride confers resistance to the antimitotic drug methyl benzimidazole-2-yl-carbamate.
Article in Molecular & general genetics : MGG, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 58 citations in OpenAlex.
- Article
- Omics for understanding the tolerant mechanism of Trichoderma asperellum TJ01 to organophosphorus pesticide dichlorvos.BMC genomics · 2018Article
- The NADPH Oxidases Nox1 and Nox2 Differentially Regulate Volatile Organic Compounds, Fungistatic Activity, Plant Growth Promotion and Nutrient Assimilation inFrontiers in microbiology · 2018Article
- Trichogenic-selenium nanoparticles enhance disease suppressive ability of Trichoderma against downy mildew disease caused by Sclerospora graminicola in pearl millet.Scientific reports · 2017Article
- Predicting Resistance by Mutagenesis: Lessons from 45 Years of MBC Resistance.Frontiers in microbiology · 2016Article
- Molecular evolution and functional divergence of tubulin superfamily in the fungal tree of life.Scientific reports · 2014Article
- Benomyl-resistant mutant strain of Trichoderma sp. with increased mycoparasitic activity.Folia microbiologica · 2010Article
- Isolation and sequence analysis of a beta-tubulin gene from arbuscular mycorrhizal fungi.Mycorrhiza · 2009Article
- Identification and characterization of benzimidazole resistance in Monilinia fructicola from stone fruit orchards in California.Applied and environmental microbiology · 2003Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We characterized a Trichoderma viride strain that is resistant to the antimitotic drug methyl benzimidazole-2-yl-carbamate (MBC). This species has two beta-tubulin genes (tub1 and tub2) and by reverse genetics we showed that a mutation in the tub2 gene confers MBC resistance in this strain. Comparison of the tub2 sequence of the mutant strain with that of the wild type revealed that a single amino acid substitution of tyrosine for histidine at a position 6 is responsible for the MBC tolerance. Furthermore, we showed that this gene can be used as a homologous dominant selectable marker in T. viride transformation. Both tubulin genes were completely sequenced. They differ by 48 residues and the degree of identity between their deduced amino acid sequences is 86.3%.
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