ReviewActa neuropathologica1993
Neuropathological changes caused by hydrocephalus.
Review in Acta neuropathologica, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
107 citing papers in PubMed, 1 synthesis or guideline pooled it, 433 citations in OpenAlex.
- Are Shunt Revisions Associated with IQ in Congenital Hydrocephalus? A Meta -Analysis.Neuropsychology review · 2016Pooled it
- Lateral Ventricle Enlargement and Cortical Thinning in Idiopathic Normal-pressure Hydrocephalus Patients.Scientific reports · 2018Trial
- Functional and magnetic resonance imaging correlates of corpus callosum in normal pressure hydrocephalus before and after shunting.Journal of neurology, neurosurgery, and psychiatry · 2007Trial
- Cognitive changes after cerebrospinal fluid shunting in young adults with spina bifida and assumed arrested hydrocephalus.Journal of neurology, neurosurgery, and psychiatry · 2000Trial
- The clinical trials landscape of hydrocephalus: a scoping review of therapeutic priorities, innovation trends, and research gaps.Neurosurgical review · 2026Article
- Ependymal cell inflammatory activation in response to intracerebral hemorrhage.Journal of neuroinflammation · 2026Article
- Effects of seasonal factors on brain function: Systematic review and future perspectives.iScience · 2025Article
- Neural stem cell changes and spatial distribution of AQP4 expression in a fetal goat model of obstructive hydrocephalus.IBRO neuroscience reports · 2025Article
- Neurogenesis and glial impairments in congenital hydrocephalus: insights from a BioGlue-induced fetal lamb model.Fluids and barriers of the CNS · 2025Article
- Ependymal cilia decline and AQP4 upregulation in young adult rats with syringomyelia.Fluids and barriers of the CNS · 2025Article
- Distinct cerebral cortical microstructural changes in idiopathic normal-pressure hydrocephalus.Frontiers in neurology · 2025Article
- The MRL Model: A Valuable Tool in Studies of Autoimmunity-Brain Interactions.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Radiological features of gait phenotypes in patients with idiopathic normal pressure hydrocephalus.Frontiers in aging neuroscience · 2025Article
- Assessing regional homogeneity and cognitive function alterations in pediatric brain tumor patients: a resting-state functional magnetic resonance imaging study.Quantitative imaging in medicine and surgery · 2024Article
- Regulation of brain fluid volumes and pressures: basic principles, intracranial hypertension, ventriculomegaly and hydrocephalus.Fluids and barriers of the CNS · 2024Review
- Loss of Katnal2 leads to ependymal ciliary hyperfunction and autism-related phenotypes in mice.PLoS biology · 2024Article
- Noradrenergic Pathways Involved in Micturition in an Animal Model of Hydrocephalus-Implications for Urinary Dysfunction.Biomedicines · 2024Article
- Brain blood flow pulse analysis may help to recognize individuals who suffer from hydrocephalus.Acta neurochirurgica · 2023Article
- A neural stem cell paradigm of pediatric hydrocephalus.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Tumor region associated with specific processing speed outcomes.Pediatric blood & cancer · 2023Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The medical literature concerning neuropathological changes caused by hydrocephalus is reviewed. In both humans and experimental animals the ependyma suffers focal destruction, cerebral blood vessels are distorted and capillaries collapse, there is damage to axons and myelin in the periventricular white matter, and occasionally neurons suffer injury. The damage appears to result from mechanical distortion of the brain combined with impaired cerebral blood flow. If ventriculomegaly develops very early, foci of cortical dysgenesis may be the result. The character and distribution of pathological changes are dependent on the age at which hydrocephalus develops, the rate and magnitude of ventricular enlargement, and the duration of hydrocephalus. Diversionary shunting of cerebrospinal fluid can only incompletely reverse the damage and the potential for reversal diminishes as the duration of hydrocephalus increases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.