ArticleMolecular and cellular biology1993
Location and characterization of autonomously replicating sequences from chromosome VI of Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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56 citing papers in PubMed.
- Cruciform-forming AT/TA repeats are acted upon by structure-selective endonucleases and Rad51 prior to repositioning to the nuclear periphery for repair.Nucleic acids research · 2026Article
- MCM2-7 loading-dependent ORC release ensures genome-wide origin licensing.Nature communications · 2024Article
- Origin recognition complex harbors an intrinsic nucleosome remodeling activity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genome-wide landscape of position effects on heterogeneous gene expression inBiotechnology for biofuels · 2017Article
- Context based computational analysis and characterization of ARS consensus sequences (ACS) of Saccharomyces cerevisiae genome.Genomics data · 2016Article
- The reference genome sequence of Saccharomyces cerevisiae: then and now.G3 (Bethesda, Md.) · 2014Article
- GC-rich DNA elements enable replication origin activity in the methylotrophic yeast Pichia pastoris.PLoS genetics · 2014Article
- Initiation of DNA replication from non-canonical sites on an origin-depleted chromosome.PloS one · 2014Article
- The dynamics of genome replication using deep sequencing.Nucleic acids research · 2014Article
- A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan.PLoS genetics · 2013Article
- A Link between ORC-origin binding mechanisms and origin activation time revealed in budding yeast.PLoS genetics · 2013Article
- Article
- Conservation of replication timing reveals global and local regulation of replication origin activity.Genome research · 2012Article
- Optimal placement of origins for DNA replication.Physical review letters · 2012Article
- Novel features of ARS selection in budding yeast Lachancea kluyveri.BMC genomics · 2011Article
- High-resolution analysis of four efficient yeast replication origins reveals new insights into the ORC and putative MCM binding elements.Nucleic acids research · 2011Article
- Mathematical modelling of whole chromosome replication.Nucleic acids research · 2010Article
- A comprehensive genome-wide map of autonomously replicating sequences in a naive genome.PLoS genetics · 2010Article
- Genome-wide estimation of firing efficiencies of origins of DNA replication from time-course copy number variation data.BMC bioinformatics · 2010Article
- Early initiation of a replication origin tethered at the nuclear periphery.Journal of cell science · 2010Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
We have reported the isolation of linking clones of HindIII and EcoRI fragments, altogether spanning a 230-kb continuous stretch of chromosome VI. The presence or absence of autonomously replicating sequence (ARS) activities in all of these fragments has been determined by using ARS searching vectors containing CEN4. Nine ARS fragments were identified, and their positions were mapped on the chromosome. Structures essential for and/or stimulative to ARS activity were determined for the ARS fragments by deletions and mutations. The organization of functional elements composed of core and stimulative sequences was found to be variable. Single core sequences were identified in eight of nine ARSs. The remaining ARS (ARS603) essential element is composed of two core-like sequences. The lengths of 3'- and 5'-flanking stimulative sequences required for the full activity of ARSs varied from ARS to ARS. Five ARSs required more than 100 bp of the 3'-flanking sequence as stimulative sequences, while not more than 79 bp of the 3' sequence was required by the other three ARSs. In addition, five ARSs had stimulative sequences varying from 127 to 312 bp in the 5'-flanking region of the core sequence. In general, these stimulative activities were correlated with low local delta Gs of unwinding, suggesting that the low local delta G of an ARS is an important element for determining the efficiency of initiation of replication of ARS plasmids.
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