ArticleMolecular and cellular biology1993
NPK1, a tobacco gene that encodes a protein with a domain homologous to yeast BCK1, STE11, and Byr2 protein kinases.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- MAPKKKs in Plants: Multidimensional Regulators of Plant Growth and Stress Responses.International journal of molecular sciences · 2023Review
- The formation of perinucleolar bodies is important for normal leaf development and requires the zinc-finger DNA-binding motif in Arabidopsis ASYMMETRIC LEAVES2.The Plant journal : for cell and molecular biology · 2020Article
- RNA-Seq Analysis Reveals MAPKKK Family Members Related to Drought Tolerance in Maize.PloS one · 2015Article
- Arabidopsis ASYMMETRIC LEAVES2 protein required for leaf morphogenesis consistently forms speckles during mitosis of tobacco BY-2 cells via signals in its specific sequence.Journal of plant research · 2012Article
- Identification of three MAPKKKs forming a linear signaling pathway leading to programmed cell death in Nicotiana benthamiana.BMC plant biology · 2012Article
- Increased leaf angle1, a Raf-like MAPKKK that interacts with a nuclear protein family, regulates mechanical tissue formation in the Lamina joint of rice.The Plant cell · 2011Article
- The PP2A regulatory subunit Tap46, a component of the TOR signaling pathway, modulates growth and metabolism in plants.The Plant cell · 2011Article
- The MAP kinase MPK4 is required for cytokinesis in Arabidopsis thaliana.The Plant cell · 2010Article
- HINKEL kinesin, ANP MAPKKKs and MKK6/ANQ MAPKK, which phosphorylates and activates MPK4 MAPK, constitute a pathway that is required for cytokinesis in Arabidopsis thaliana.Plant & cell physiology · 2010Article
- A Raf-like MAPKKK gene DSM1 mediates drought resistance through reactive oxygen species scavenging in rice.Plant physiology · 2010Article
- Systematic analysis of NPK1-like genes in rice reveals a stress-inducible gene cluster co-localized with a quantitative trait locus of drought resistance.Molecular genetics and genomics : MGG · 2008Article
- Interaction between Agrobacterium tumefaciens oncoprotein 6b and a tobacco nucleolar protein that is homologous to TNP1 encoded by a transposable element of Antirrhinum majus.Journal of plant research · 2008Article
- Phosphorylation of NtMAP65-1 by a MAP kinase down-regulates its activity of microtubule bundling and stimulates progression of cytokinesis of tobacco cells.Genes & development · 2006Article
- Arabidopsis kinome: after the casting.Functional & integrative genomics · 2004Review
- Expression of an active tobacco mitogen-activated protein kinase kinase kinase enhances freezing tolerance in transgenic maize.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- NQK1/NtMEK1 is a MAPKK that acts in the NPK1 MAPKKK-mediated MAPK cascade and is required for plant cytokinesis.Genes & development · 2003Article
- Control of plant cytokinesis by an NPK1-mediated mitogen-activated protein kinase cascade.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2002Review
- An Arabidopsis mitogen-activated protein kinase kinase kinase gene family encodes essential positive regulators of cytokinesis.The Plant cell · 2002Article
- The protein encoded by oncogene 6b from Agrobacterium tumefaciens interacts with a nuclear protein of tobacco.The Plant cell · 2002Article
- The NPK1 mitogen-activated protein kinase kinase kinase is a regulator of cell-plate formation in plant cytokinesis.Genes & development · 2001Article
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7 authors.
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Abstract
We have isolated a cDNA (cNPK1) that encodes a predicted protein kinase of 690 amino acids from suspension cultures of tobacco cells. The deduced sequence is closely related to those of the protein kinases encoded by the STE11 and BCK1 genes of Saccharomyces cerevisiae and the byr2 gene of Schizosaccharomyces pombe. STE11 and Byr2 function in the yeast mating pheromone response pathways, and BCK1 acts downstream of the yeast protein kinase C homolog encoded by the PKC1 gene, which is essential for normal growth and division of yeast cells. Overexpression in yeast cells of a truncated form of cNPK1, which encodes only the putative catalytic domain, replaced the growth control functions of BCK1 and PKC1 but not the mating pheromone response function of STE11. Thus, the catalytic domain of NPK1 specifically activates the signal transduction pathway mediated by BCK1 in yeast. In tobacco cells in suspension culture, the NPK1 gene is transcribed during logarithmic phase and early stationary phase but not during late stationary phase. In a tobacco plant, it is also transcribed in stems and roots but not in mature leaves, which rarely contain growing cells. The present results suggest that a signal transduction pathway mediated by this BCK1- and STE11-related protein kinase is also conserved in plants and that a function of NPK1 is controlled at least in part at a transcriptional level.
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