ArticleMolecular and cellular biology1993
Developmental differences in methylation of human Alu repeats.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 132 citations in OpenAlex.
- Article
- Genetic and in utero environmental contributions to DNA methylation variation in placenta.Human molecular genetics · 2021Article
- Immediate and durable effects of maternal tobacco consumption alter placental DNA methylation in enhancer and imprinted gene-containing regions.BMC medicine · 2020Article
- AP-TSS: A New Method for the Analysis of RNA Expression from Particular and Challenging Transcription Start Sites.Biomolecules · 2020Article
- Integrated Systems Biology Approach Identifies Novel Maternal and Placental Pathways of Preeclampsia.Frontiers in immunology · 2018Article
- Genomic landscape of CpG rich elements in human.BMC evolutionary biology · 2017Article
- The epigenetic landscape of Alu repeats delineates the structural and functional genomic architecture of colon cancer cells.Genome research · 2017Article
- Placental Hypomethylation Is More Pronounced in Genomic Loci Devoid of Retroelements.G3 (Bethesda, Md.) · 2016Article
- Growth signals employ CGGBP1 to suppress transcription of Alu-SINEs.Cell cycle (Georgetown, Tex.) · 2016Article
- DNA methylation variation of human-specific Alu repeats.Epigenetics · 2016Article
- Retrotransposon hypomethylation in melanoma and expression of a placenta-specific gene.PloS one · 2014Article
- Dynamic Alu methylation during normal development, aging, and tumorigenesis.BioMed research international · 2014Review
- DNA methylation profiling in human B cells reveals immune regulatory elements and epigenetic plasticity at Alu elements during B-cell activation.Genome research · 2013Article
- The origin of the RB1 imprint.PloS one · 2013Article
- Different measures of "genome-wide" DNA methylation exhibit unique properties in placental and somatic tissues.Epigenetics · 2012Article
- Article
- Genetic variation in cholinergic muscarinic-2 receptor gene modulates M2 receptor binding in vivo and accounts for reduced binding in bipolar disorder.Molecular psychiatry · 2011Article
- Restless genomes humans as a model organism for understanding host-retrotransposable element dynamics.Advances in genetics · 2011Review
- All y'all need to know 'bout retroelements in cancer.Seminars in cancer biology · 2010Review
- BISMA--fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences.BMC bioinformatics · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Alu repeats are especially rich in CpG dinucleotides, the principal target sites for DNA methylation in eukaryotes. The methylation state of Alus in different human tissues is investigated by simple, direct genomic blot analysis exploiting recent theoretical and practical advances concerning Alu sequence evolution. Whereas Alus are almost completely methylated in somatic tissues such as spleen, they are hypomethylated in the male germ line and tissues which depend on the differential expression of the paternal genome complement for development. In particular, we have identified a subset enriched in young Alus whose CpGs appear to be almost completely unmethylated in sperm DNA. The existence of this subset potentially explains the conservation of CpG dinucleotides in active Alu source genes. These profound, sequence-specific developmental changes in the methylation state of Alu repeats suggest a function for Alu sequences at the DNA level, such as a role in genomic imprinting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.