ArticleThe Journal of cell biology1993
Distinct roles of the Drosophila ninaC kinase and myosin domains revealed by systematic mutagenesis.
Article in The Journal of cell biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 120 citations in OpenAlex.
- Characterization of a novel MYO3A missense mutation associated with a dominant form of late onset hearing loss.Scientific reports · 2018Trial
- Genome assembly of an endemic butterfly (Minois Aurata) shed light on the genetic mechanisms underlying ecological adaptation to arid valley habitat.BMC genomics · 2024Article
- Impact of the Motor and Tail Domains of Class III Myosins on Regulating the Formation and Elongation of Actin Protrusions.The Journal of biological chemistry · 2016Article
- Common mechanisms regulating dark noise and quantum bump amplification in Drosophila photoreceptors.Journal of neurophysiology · 2013Article
- A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIA.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Dependence on a retinophilin/myosin complex for stability of PKC and INAD and termination of phototransduction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Retinophilin is a light-regulated phosphoprotein required to suppress photoreceptor dark noise in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Building a fly eye: terminal differentiation events of the retina, corneal lens, and pigmented epithelia.Current topics in developmental biology · 2010Review
- Cloning and distribution of myosin 3B in the mouse retina: differential distribution in cone outer segments.Experimental eye research · 2009Article
- Article
- Prolonged G(q) activity triggers fly rhodopsin endocytosis and degradation, and reduces photoreceptor sensitivity.The EMBO journal · 2007Article
- Loop 2 of limulus myosin III is phosphorylated by protein kinase A and autophosphorylation.Biochemistry · 2007Article
- A new compartment at stereocilia tips defined by spatial and temporal patterns of myosin IIIa expression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Dissecting independent channel and scaffolding roles of the Drosophila transient receptor potential channel.The Journal of cell biology · 2005Article
- Localization of a class III myosin to filopodia tips in transfected HeLa cells requires an actin-binding site in its tail domain.Molecular biology of the cell · 2003Article
- Myo3A, one of two class III myosin genes expressed in vertebrate retina, is localized to the calycal processes of rod and cone photoreceptors and is expressed in the sacculus.Molecular biology of the cell · 2003Article
- TRP and the PDZ protein, INAD, form the core complex required for retention of the signalplex in Drosophila photoreceptor cells.The Journal of cell biology · 2000Article
- Modulation of the light response by cAMP in Drosophila photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Genetic dissection of behavior: modulation of locomotion by light in the Drosophila melanogaster larva requires genetically distinct visual system functions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Unconventional myosins at the crossroad of signal transduction and cytoskeleton remodeling.Protoplasma · 1999Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The Drosophila ninaC locus encodes a rhabdomere specific protein (p174) with linked protein kinase and myosin domains, required for a wild-type ERG and to prevent retinal degeneration. To investigate the role for linked kinase and myosin domains, we analyzed mutants generated by site-directed mutagenesis. Mutation of the kinase domain resulted in an ERG phenotype but no retinal degeneration. Deletion of the myosin domain caused a change in the subcellular distribution of p174 and resulted in both ERG and retinal degeneration phenotypes. Temperature-sensitive mutations in the myosin domain resulted in retinal degeneration, but no ERG phenotype. These results indicated that the ERG and retinal degeneration phenotypes were not strictly coupled suggesting that the myosin domain has multiple functions. We propose that the role of the kinase domain is to regulate other rhabdomeric proteins important in phototransduction and that the myosin domain has at least two roles: to traffic the kinase into the rhabdomeres and to maintain the rhabdomeres.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.