ArticleInfection and immunity1993
Gamma interferon levels during Chlamydia trachomatis pneumonia in mice.
Article in Infection and immunity, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Role of IFN-γ from Different Immune Cells inMicroorganisms · 2025Review
- Article
- γδT cells in oral tissue immune surveillance and pathology.Frontiers in immunology · 2022Review
- An Ancient Molecular Arms Race:Frontiers in immunology · 2020Review
- T Cell-Independent Gamma Interferon and B Cells Cooperate To Prevent Mortality Associated with Disseminated Chlamydia muridarum Genital Tract Infection.Infection and immunity · 2018Article
- Differential effects of type I and II interferons on myeloid cells and resistance to intracellular bacterial infections.Immunologic research · 2013Review
- Article
- Enhanced virulence of Chlamydia muridarum respiratory infections in the absence of TLR2 activation.PloS one · 2011Article
- Role of NK cells in early host response to chlamydial genital infection.Infection and immunity · 1998Article
- Local immune responses to Chlamydia pneumoniae in the lungs of BALB/c mice during primary infection and reinfection.Infection and immunity · 1998Article
- T lymphocyte immunity in host defence against Chlamydia trachomatis and its implication for vaccine development.The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses · 1998Article
- Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis.Infection and immunity · 1997Article
- Evidence for a predominant proinflammatory conjunctival cytokine response in individuals with trachoma.Infection and immunity · 1996Article
- Functional difference between Thy-1-positive and Thy-1-negative gamma delta T cells induced by Escherichia coli infection in mice.Immunology · 1996Article
- A model of genital Chlamydia trachomatis infection using human xenografts in severe combined immunodeficiency mice.Infection and immunity · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Host defense against murine Chlamydia trachomatis (mouse pneumonitis agent [MoPn]) in a murine model was investigated. Gamma interferon (IFN-gamma) was produced in the lungs by both MoPn-susceptible nude athymic (nu/nu) and MoPn-resistant heterozygous (nu/+) mice. In vivo depletion of IFN-gamma in nu/nu mice led to exacerbation of infection. Fluorescence-activated cell sorter analysis disclosed induction of GL3 antibody-positive cells (putatively gamma/delta+ T cells) in nu/nu mouse lung during infection with MoPn. Treatment of nu/nu mice in vivo with antibody to NK cells (anti-asialo GM1 antibody) or to gamma/delta cells (UC7-13D5) did not significantly decrease IFN-gamma production in the lung. However, treatment of severe combined immunodeficiency mice (which lack gamma/delta cells) with antibody to NK cells significantly reduced lung IFN-gamma levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.