ArticleInfection and immunity1993
Differential host susceptibility to intracerebral infections with Candida albicans and Cryptococcus neoformans.
Article in Infection and immunity, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Clinical and pathological characterization of Central Nervous System cryptococcosis in an experimental mouse model of stereotaxic intracerebral infection.PLoS neglected tropical diseases · 2023Article
- Pathogenic Fungal Infection in the Lung.Frontiers in immunology · 2019Review
- Kynurenine Pathway in Skin Cells: Implications for UV-Induced Skin Damage.International journal of tryptophan research : IJTR · 2012Article
- Characterization of the kynurenine pathway in human neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Host defence to pulmonary mycosis.The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses · 1999Article
- Enhanced resistance to Cryptococcus neoformans infection induced by chloroquine in a murine model of meningoencephalitis.Antimicrobial agents and chemotherapy · 1997Article
- Potent antifungal effects of a new derivative of partricin A in a murine model of cerebral cryptococcosis.Antimicrobial agents and chemotherapy · 1997Article
- Effects of pentoxifylline or dexamethasone in combination with amphotericin B in experimental murine cerebral cryptococcosis: evidence of neuroexcitatory pathogenic mechanisms.Antimicrobial agents and chemotherapy · 1996Article
- L3T4(CD4)-, Lyt-2(CD8)- and Mac-1(CD11b)-phenotypic leukocytes in murine cryptococcal meningoencephalitis.Mycopathologia · 1995Article
- Adhesion of Candida albicans to brain tissue of Macaca mulata in an ex vivo assay.Infection and immunity · 1995Article
- Beta-1,2-linked oligomannosides from Candida albicans act as signals for tumor necrosis factor alpha production.Infection and immunity · 1995Article
- Differential susceptibility of yeast and hyphal forms of Candida albicans to proteolytic activity of macrophages.Infection and immunity · 1995Article
- Biomolecular events involved in anticryptococcal resistance in the brain.Infection and immunity · 1995Article
- Cytokine treatment of central nervous system infection: efficacy of interleukin-12 alone and synergy with conventional antifungal therapy in experimental cryptococcosis.Antimicrobial agents and chemotherapy · 1994Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the immune defense mechanisms employed against fungi in the brain, mice were experimentally infected by intracerebral inoculation of Candida albicans or Cryptococcus neoformans. Parameters such as median survival time and numbers of yeast cells in the brains were assessed for naive and immunomodulated mice. We found that no mice survived either C. albicans or C. neoformans challenge at doses of > or = 10(6) yeast cells per mouse. However, when the inoculum size was decreased (< or = 10(5) yeast cells per mouse), C. albicans was no longer lethal (100% survival), whereas 100 and 70% of the mice still succumbed to challenge doses of 10(4) and 10(3) C. neoformans yeast cells, respectively. Pharmacological manipulation and transfer experiments revealed that the myelomonocytic compartment had a minor role against C. neoformans but was deeply involved in the control of intracerebral C. albicans infection. By counting the number of yeast cells in the brains of naive and immunomodulated animals, we established that, unlike C. albicans, C. neoformans remained essentially in the brain, where massive colonization and damage occurred whether naive or immunomodulated defense mechanisms were employed by the host. Overall, these data suggest that the differential role of the myelomonocytic compartment, together with the diverse tropisms of the two fungi, can explain the different development and outcome of intracerebral C. albicans and C. neoformans infections.
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