ArticleInfection and immunity1993
Calcium-dependent protein kinase C activity of neutrophils in localized juvenile periodontitis.
Article in Infection and immunity, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 42 citations in OpenAlex.
- Impaired neutrophil directional chemotactic accuracy in chronic periodontitis patients.Journal of clinical periodontology · 2015Article
- Ceruloplasmin induces polymorphonuclear leukocyte priming in localized aggressive periodontitis.Journal of periodontology · 2009Article
- AZT-induced oxidative cardiovascular toxicity: attenuation by Mg-supplementation.Cardiovascular toxicology · 2009Article
- Priming of neutrophil oxidative burst in diabetes requires preassembly of the NADPH oxidase.Journal of leukocyte biology · 2008Article
- CD38 expression in neutrophils from patients with localized aggressive periodontitis.Journal of periodontology · 2005Article
- Enhanced superoxide release and elevated protein kinase C activity in neutrophils from diabetic patients: association with periodontitis.Journal of leukocyte biology · 2005Article
- Simultaneous measurements of cytoplasmic Ca2+ responses and intracellular pH in neutrophils of localized aggressive periodontitis (LAP) patients.Journal of leukocyte biology · 2005Article
- Localized aggressive periodontitis is linked to human chromosome 1q25.Human genetics · 2004Article
- Protein kinase C: a family of isoenzymes with distinct roles in pathogenesis.Clinical molecular pathology · 1995Article
- Evaluation of peripheral neutrophil functions in aggressive periodontitis patients and their family members in Indian population: An assessment of neutrophil chemotaxis, phagocytosis, and microbicidal activity.Journal of Indian Society of PeriodontologyArticle
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Protein kinase C is a key molecule in neutrophil signal transduction after receptor stimulation by soluble bioactive molecules. It has been reported that neutrophils from most patients with localized juvenile periodontitis (LJP) do not have a normal response after stimulation with a chemotactic ligand such as N-formylmethionylleucylphenylalanine (FMLP). To further clarify the mechanism of this altered response and to confirm and expand earlier observations, the calcium-dependent protein kinase C activity of neutrophils from patients with LJP was evaluated. Peripheral blood neutrophils from 12 patients and 12 healthy subjects, age, sex, and race matched, were sonicated and subsequently subfractionated by ultracentrifugation into a soluble fraction (cytosol rich) and a particulate fraction (membrane rich). The calcium-dependent protein kinase C activity was evaluated in each fraction by phosphorylation of histone with radiolabeled ATP in the presence or in the absence of phorbol 12-myristate 13-acetate stimulation. Results revealed that the total calcium-dependent protein kinase C activity of neutrophils from patients with LJP and depressed chemotactic migration to FMLP (201.0 +/- 63.6 pmol/min/10(7) cells) was lower than that of neutrophils from healthy subjects (287.6 +/- 55.7 pmol/min/10(7) cells) (P < 0.01). The calcium-dependent protein kinase C activity in neutrophils from patients with LJP exhibited a positive correlation with chemotactic migration to FMLP (P < 0.05). The low activity of calcium-dependent protein kinase C in neutrophils from the patients reflected the low activity in the soluble fraction from the neutrophils. After stimulation with phorbol 12-myristate 13-acetate, the calcium-dependent protein kinase C activity was found to be lower from patients with LJP than from healthy subjects. These results suggest that lower calcium-dependent protein kinase C in neutrophils is a predisposing factor for LJP.
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