ArticleInfection and immunity1993
Role of the YadA protein in prevention of opsonization of Yersinia enterocolitica by C3b molecules.
Article in Infection and immunity, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- A comprehensive review of genomic-scale genetic engineering as a strategy to improve bacterial productivity.Microbiology (Reading, England) · 2025Review
- Yersinia enterocolitica in Crohn's disease.Frontiers in cellular and infection microbiology · 2023Review
- Innate Immune Pattern Recognition Receptors of Mycobacterium tuberculosis: Nature and Consequences for Pathogenesis of Tuberculosis.Advances in experimental medicine and biology · 2021Article
- Population genetic analysis of autophagy and phagocytosis genes in Drosophila melanogaster and D. simulans.PloS one · 2018Article
- Vitronectin Binds to a Specific Stretch within the Head Region of Yersinia Adhesin A and Thereby Modulates Yersinia enterocolitica Host Interaction.Journal of innate immunity · 2017Article
- Article
- The rickettsial OmpB β-peptide of Rickettsia conorii is sufficient to facilitate factor H-mediated serum resistance.Infection and immunity · 2012Article
- Oligomeric coiled-coil adhesin YadA is a double-edged sword.PloS one · 2010Article
- Complement control protein factor H: the good, the bad, and the inadequate.Molecular immunology · 2010Review
- Trimer stability of YadA is critical for virulence of Yersinia enterocolitica.Infection and immunity · 2010Article
- Functional comparison of the binding of factor H short consensus repeat 6 (SCR 6) to factor H binding protein from Neisseria meningitidis and the binding of factor H SCR 18 to 20 to Neisseria gonorrhoeae porin.Infection and immunity · 2009Article
- Growth of Yersinia pseudotuberculosis in human plasma: impacts on virulence and metabolic gene expression.BMC microbiology · 2008Article
- Functional mapping of YadA- and Ail-mediated binding of human factor H to Yersinia enterocolitica serotype O:3.Infection and immunity · 2008Article
- Effect of flagellar mutations on Yersinia enterocolitica biofilm formation.Applied and environmental microbiology · 2008Article
- Characterization of complement factor H binding to Yersinia enterocolitica serotype O:3.Infection and immunity · 2008Article
- Yersinia enterocolitica serum resistance proteins YadA and ail bind the complement regulator C4b-binding protein.PLoS pathogens · 2008Article
- Contribution of trimeric autotransporter C-terminal domains of oligomeric coiled-coil adhesin (Oca) family members YadA, UspA1, EibA, and Hia to translocation of the YadA passenger domain and virulence of Yersinia enterocolitica.Journal of bacteriology · 2008Article
- Complement is an essential component of the immune response to adeno-associated virus vectors.Journal of virology · 2008Article
- The opportunistic human pathogenic fungus Aspergillus fumigatus evades the host complement system.Infection and immunity · 2008Article
- A conserved glycine residue of trimeric autotransporter domains plays a key role in Yersinia adhesin A autotransport.Journal of bacteriology · 2007Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When mixed with normal human serum, wild-type pathogenic Yersinia enterocolitica, previously incubated at 37 degrees C, fixed less C3b than its variant cured of the virulence plasmid pYV. Mutants unable to secrete the Yop proteins were still protected against C3b deposition. By contrast, mutants deficient in the production of outer membrane protein YadA fixed more C3b than their YadA+ parent. Gene yadA, cloned as a minimal polymerase chain reaction fragment and introduced in trans, complemented the mutations. Production of YadA by recombinant Escherichia coli LK111 also resulted in a reduction of the amount of C3b deposited on the bacterial surface. The reduction of C3b at the surface of Y. enterocolitica YadA+ compared with YadA- cells correlated with an increase of the amount of factor H fixed at the bacterial surface. The YadA monomer separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and transferred to a nitrocellulose membrane was able to bind factor H. We conclude that factor H bound to YadA reduces the C3b deposition on the bacterial surface, probably by a rapid inactivation of C3b.
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