Trial reportDiabetologia1993
Early glomerulopathy is present in young, type 1 (insulin-dependent) diabetic patients with microalbuminuria.
Trial report in Diabetologia, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Insulin and glucose-lowering agents for treating people with diabetes and chronic kidney disease.The Cochrane database of systematic reviews · 2018Pooled it
- SNP in the genome-wide association study hotspot on chromosome 9p21 confers susceptibility to diabetic nephropathy in type 1 diabetes.Diabetologia · 2012Pooled it
- The effects of candesartan on diabetes glomerulopathy: a double-blind, placebo-controlled trial.Pediatric nephrology (Berlin, Germany) · 2008Trial
- Improvement of blood glucose control in IDDM patients retards the progression of morphological changes in early diabetic nephropathy.Diabetologia · 1994Trial
- Pros and cons of live kidney donation in prediabetics: A critical review and way forward.World journal of transplantation · 2024Review
- U-shaped relationship between fasting blood glucose and urinary albumin-to-creatinine ratio in the general United States population.Frontiers in endocrinology · 2024Article
- Previous Exercise Training Reduces Markers of Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Female Rats.Journal of diabetes research · 2018Article
- Beneficial effects of previous exercise training on renal changes in streptozotocin-induced diabetic female rats.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- Regression and progression of microalbuminuria in adolescents with childhood onset diabetes mellitus.Annals of pediatric endocrinology & metabolism · 2015Article
- Spot urine albumin to creatinine ratio and serum cystatin C are effective for detection of diabetic nephropathy in childhood diabetic patients.Journal of Korean medical science · 2012Article
- Risk of microalbuminuria and progression to macroalbuminuria in a cohort with childhood onset type 1 diabetes: prospective observational study.BMJ (Clinical research ed.) · 2008 · on this mapArticle
- Widening of foot processes in normoalbuminuric adolescents with type 1 diabetes.Pediatric nephrology (Berlin, Germany) · 2005Article
- Follow-up of kidney biopsies in normoalbuminuric patients with type 1 diabetes.Pediatric nephrology (Berlin, Germany) · 2004Article
- Predictors for the development of microalbuminuria and macroalbuminuria in patients with type 1 diabetes: inception cohort study.BMJ (Clinical research ed.) · 2004Article
- Risk predictors in patients with diabetic nephropathy.Current diabetes reports · 2001Review
- Is it possible to predict diabetic kidney disease?Journal of endocrinological investigation · 2000Review
- Podocyte loss and progressive glomerular injury in type II diabetes.The Journal of clinical investigation · 1997Article
- A quantitative ultrastructural study of juxtaglomerular arterioles in IDDM patients with micro- and normoalbuminuria.Diabetologia · 1995Article
- Glomerular epithelial foot processes and filtration slits in IDDM patients.Diabetologia · 1995Article
- Diabetic Kidney Disease: A Syndrome Rather Than a Single Disease.The review of diabetic studies : RDSReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased urinary albumin excretion, microalbuminuria, may be the first sign of early diabetic nephropathy. We examined glomeruli by morphometric methods in 17 patients with Type 1 (insulin-dependent) diabetes mellitus and microalbuminuria. The median age was 19 (range 18-29) years, duration of diabetes 12 (8-15) years, mean blood pressure 93 (87-115) mm Hg, glomerular filtration rate 132 (101-209) ml.min-1.1.73 m2 -2, albumin excretion rate (mean over 1 year) 32 (15-194) micrograms/min. Reference data were obtained from 11 healthy kidney donors. Mesangial volume estimates were obtained by serial sectioning in three total profiles in each of three glomeruli in diabetic patients. Basement membrane thickness and matrix volume fraction were estimated from one level per glomerulus. Two matrix parameters, matrix star volume and matrix thickness, were estimated. Interstitial volume fraction in cortex was measured by light microscopy. The morphological parameters were significantly increased in the diabetic group compared to the control group, basement membrane thickness (mean with 95% confidence intervals) was 595 nm (549-641 nm) vs 305 nm (287-325 nm), p = 0.0001; mesangial volume fraction 0.22 (0.21-0.23) vs 0.19 (0.18-0.21), p = 0.04, and matrix volume fraction 0.13 (0.12-0.13 vs 0.09 (0.08-0.10), p = 0.001. Also matrix star volume and thickness, interstitial volume fraction and mean capillary diameter were significantly increased. The intra-individual variation among glomeruli expressed as coefficient of variation was 7.4% vs 9% (basement membrane thickness) and 11.7% vs 25% (mesangial volume fraction) in the diabetic and the control group, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.