ArticleThe EMBO journal1993
Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal.
Article in The EMBO journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 172 citations in OpenAlex.
- Imbalance of c-MPL Isoform Promotes Tumorigenesis by Activating STAT-5 in Leukemic Cell Lines.Current issues in molecular biology · 2026Article
- TET2 deficiency increases the competitive advantage of hematopoietic stem and progenitor cells through upregulation of thrombopoietin receptor signaling.Nature communications · 2025Article
- A review on the functional characteristics of the c-Myeloproliferative Leukaemia (c-MPL) gene and its isoforms.Cellular oncology (Dordrecht, Netherlands) · 2024Review
- The oncogenic function of PLAGL2 is mediated via ASCL2 and IGF2 and a Wnt-independent mechanism in colorectal cancer.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Splicing Anomalies in Myeloproliferative Neoplasms: Paving the Way for New Therapeutic Venues.Cancers · 2020Review
- Novel hematopoietic progenitor populations revealed by direct assessment of GATA1 protein expression and cMPL signaling events.Stem cells (Dayton, Ohio) · 2011Article
- Extracellular domain N-glycosylation controls human thrombopoietin receptor cell surface levels.Frontiers in endocrinology · 2011Article
- Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production.Oncogene · 2002Review
- Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity.The Journal of clinical investigation · 2001Article
- Defective megakaryopoiesis and abnormal erythroid development in Fli-1 gene-targeted mice.International journal of hematology · 2001Article
- A new feature of Mpl receptor: ligand-induced transforming activity in FRE rat fibroblasts.Oncogene · 2000Article
- Article
- Permissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decisions in vivo.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Human thrombopoietin structure-function relationships: identification of functionally important residues.The Biochemical journal · 1998Article
- Thrombopoietin stimulates proliferation and megakaryocytic differentiation of mouse pro-B cell line BF-TE22.Cytotechnology · 1998Article
- The thrombopoietin receptor can mediate proliferation without activation of the Jak-STAT pathway.The Journal of experimental medicine · 1997Article
- Control of thrombopoietin-induced megakaryocytic differentiation by the mitogen-activated protein kinase pathway.Molecular and cellular biology · 1997Article
- Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The murine myeloproliferative leukemia virus has previously been shown to contain a fragment of the coding region of the c-mpl gene, a member of the cytokine receptor superfamily. We have isolated cDNA and genomic clones encoding murine c-mpl and localized the c-mpl gene to mouse chromosome 4. Since some members of this superfamily function by transducing a proliferative signal and since the putative ligand of mpl is unknown, we have generated a chimeric receptor to test the functional potential of mpl. The chimera consists of the extracellular domain of the human interleukin-4 receptor and the cytoplasmic domain of mpl. A mouse hematopoietic cell line transfected with this construct proliferates in response to human interleukin-4, thereby demonstrating that the cytoplasmic domain of mpl contains all elements necessary to transmit a growth stimulatory signal. In addition, we show that 25-40% of mpl mRNA found in the spleen corresponds to a novel truncated and potentially soluble isoform of mpl and that both full-length and truncated forms of mpl protein can be immunoprecipitated from lysates of transfected COS cells. Interestingly, however, although the truncated form of the receptor possesses a functional signal sequence and lacks a transmembrane domain, it is not detected in the culture media of transfected cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.