ArticleVirchows Archiv. A, Pathological anatomy and histopathology1993
Morphometric analysis of small intestinal mucosa. IV. Determining cell volumes.
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Proteomic and functional profiling of suspended jejunal enteroids reveals pharmacokinetic fidelity to native intestine.iScience · 2026Article
- Epithelial Abnormalities in the Small Intestine of Zambian Children With Stunting.Frontiers in medicine · 2022Article
- The distribution of cellular turnover in the human body.Nature medicine · 2021Article
- From 2-dimensional to 3-dimensional: Overcoming dilemmas in intestinal mucosal interpretation.World journal of gastroenterology · 2019Review
- Diagnosing celiac disease: A critical overview.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019Review
- Kinetic analysis of transcellular passage of the cobalamin-transcobalamin complex in Caco-2 monolayers.Molecular biology of the cell · 2019Article
- Computational Modeling of Glucose Uptake in the Enterocyte.Frontiers in physiology · 2019Article
- Article
- Evolutionary Developments in Interpreting the Gluten-Induced Mucosal Celiac Lesion: An Archimedian Heuristic.Nutrients · 2017Review
- Coeliac disease, mucosal change and IEL: doing what counts the best.Gastroenterology and hepatology from bed to bench · 2016Article
- What is the best histopathological classification for celiac disease? Does it matter?Gastroenterology and hepatology from bed to bench · 2015Article
- A "proteomic ruler" for protein copy number and concentration estimation without spike-in standards.Molecular & cellular proteomics : MCP · 2014Article
- Extensive quantitative remodeling of the proteome between normal colon tissue and adenocarcinoma.Molecular systems biology · 2012Article
- Morphometric analysis of intestinal mucosa. VI--Principles in enumerating intra-epithelial lymphocytes.Virchows Archiv : an international journal of pathology · 1994Article
- A primary cell-basedGut microbesArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was concerned with the measurement of volumes of surface epithelial cells in human small intestine, both in disease-control subjects and, for comparison, in patients with gluten sensitivity. Four procedures were employed, of which two were geometrical, based on cylindrical or truncated conoid models. The third method evolved from the proportionality of area to volume, and required determination of cellular and nuclear profile areas, and an estimation of nuclear volume based on models conforming to (1) a prolate spheroid, or (2) a cylinder with hemispherical caps. This procedure appeared to underestimate enterocyte volumes and failed to reveal volume differences between controls and gluten-sensitive individuals. Finally, a fourth method was devised, based on traditional intraepithelial profile counts per hundred enterocyte nuclei, calculation of surface epithelial volume and of the absolute number of lymphocytes contained therein. Enterocyte volumes appeared to be overestimated twofold by this procedure compared with the first two geometric methods. The results of this study indicate that the cuboidal-type enterocyte profiles typical of the untreated mucosa in gluten sensitivity are a reflection of cells with a reduced volume. From the number of enterocytes and the absolute lymphocyte population present within a morphometrically defined volume of surface epithelium, the ratios of intraepithelial lymphocytes to enterocytes were found to be 50% less than conventional density-profile counts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.