ArticleJournal of virology1993
Complete nucleotide sequence of an Amerindian human T-cell lymphotropic virus type II (HTLV-II) isolate: identification of a variant HTLV-II subtype b from a Guaymi Indian.
Article in Journal of virology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 64 citations in OpenAlex.
- HTLV-1 and HTLV-2 Infection Among Warao Indigenous Refugees in the Brazilian Amazon: Challenges for Public Health in Times of Increasing Migration.Frontiers in public health · 2022Article
- Review
- Molecular evidence for infection by HTLV-2 among individuals with negative serological screening tests for HTLV antibodies.Epidemiology and infection · 2007Article
- Tax & rex: overlapping genes of the Deltaretrovirus group.Virus genes · 2006Article
- High seroprevalence of human T-cell lymphotropic virus type 1 in blood donors in Guyana and molecular and phylogenetic analysis of new strains in the Guyana shelf (Guyana, Suriname, and French Guiana).Journal of clinical microbiology · 2004Article
- Different population dynamics of human T cell lymphotropic virus type II in intravenous drug users compared with endemically infected tribes.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Cloning and expression of a human T-lymphotropic virus type 1 protein with reverse transcriptase activity.Journal of virology · 1998Article
- African origin of human T-lymphotropic virus type 2 (HTLV-2) supported by a potential new HTLV-2d subtype in Congolese Bambuti Efe Pygmies.Journal of virology · 1998Article
- Review
- Complete nucleotide sequence of the new simian T-lymphotropic virus, STLV-PH969 from a Hamadryas baboon, and unusual features of its long terminal repeat.Journal of virology · 1997Article
- Functional identification of nucleotides conferring substrate specificity to retroviral integrase reactions.Journal of virology · 1997Article
- Identification and characterization of a new and distinct molecular subtype of human T-cell lymphotropic virus type 2.Journal of virology · 1996Article
- Human endogenous retroviruses: nature, occurrence, and clinical implications in human disease.Clinical microbiology reviews · 1996Review
- Geographical clustering of human T-cell lymphotropic virus type 1 infection in Honduras.Journal of clinical microbiology · 1995Article
- Isolation and molecular characterization of a human T-cell lymphotropic virus type II (HTLV-II), subtype B, from a healthy Pygmy living in a remote area of Cameroon: an ancient origin for HTLV-II in Africa.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Phylogenetic relationship and geographic distribution of multiple human T-cell lymphotropic virus type II subtypes.Journal of virology · 1995Article
- Genotypic characteristics of HTLV-II isolates from Amerindian and non-Indian populations.Virus genes · 1995Article
- Molecular analysis of human T-cell lymphotropic virus type II from Wayuu Indians of Colombia demonstrates two subtypes of HTLV-IIb.Virus genes · 1995Article
- A primate T-lymphotropic virus, PTLV-L, different from human T-lymphotropic viruses types I and II, in a wild-caught baboon (Papio hamadryas).Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Identification and characterization of an extended Tax protein in human T-cell lymphotropic virus type II subtype b isolates.Journal of virology · 1993Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complete nucleotide sequence of a human T-cell lymphotropic virus type II (HTLV-II) isolate from a Panamanian Guaymi Indian was determined and analyzed. When this new viral isolate (HTLV-IIG12) was compared with prototypic HTLV-IIMoT, the overall nucleotide sequence similarity was 95.4%, while the predicted amino acid sequence similarity was 97.5%. Although the overall percentage of nucleotide and amino acid identity with prototypic HTLV-IIMoT (subtype a) was high, HTLV-IIG12 displayed several distinctive features that defined it as an HTLV-II subtype b. However, there were several characteristics unique to this isolate, which included a cluster of nucleotide substitutions in the pre-gag region and changes in restriction enzyme sites within the pre-gag region and the gag, pol, env, and pX genes. In addition, two nucleotide changes in the C terminus of the Tax protein coding sequence inserted an Arg residue for a stop codon and appeared to result in a larger tax gene product in HTLV-IIG12. Although the HTLV-IIG12 isolate appears to be a variant of the prototypic HTLV-IIb, this information represents the first complete nucleotide sequence of any HTLV-II subtype b. These data will allow further studies on the evolutionary relationships between the HTLV-II subtypes and between HTLV-I and HTLV-II.
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