Trial reportBMJ (Clinical research ed.)1993
Uptake of cystic fibrosis testing in primary care: supply push or demand pull?
Trial report in BMJ (Clinical research ed.), 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 6 syntheses or guidelines pooled it, 199 citations in OpenAlex.
- Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease.The Cochrane database of systematic reviews · 2021Pooled it
- Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease.The Cochrane database of systematic reviews · 2018Pooled it
- Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease.The Cochrane database of systematic reviews · 2015Pooled it
- Preconception care: promoting reproductive planning.Reproductive health · 2014Pooled it
- Increasing informed uptake and non-uptake of screening: evidence from a systematic review.Health expectations : an international journal of public participation in health care and health policy · 2001Pooled it
- The genetic testing of children. Working Party of the Clinical Genetics Society (UK)Journal of medical genetics · 1994Guideline
- Cystic fibrosis carrier population screening in the primary care setting.American journal of human genetics · 1996Trial
- Antenatal screening for carriers of cystic fibrosis: randomised trial of stepwise v couple screening.BMJ (Clinical research ed.) · 1995Trial
- Antenatal screening for cystic fibrosis: a trial of the couple model.BMJ (Clinical research ed.) · 1994Trial
- Societal implications of expanded universal carrier screening: a scoping review.European journal of human genetics : EJHG · 2023Article
- The evolving landscape of expanded carrier screening: challenges and opportunities.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Review
- Approaches to carrier testing and results disclosure in translational genomics research: The clinical sequencing exploratory research consortium experience.Molecular genetics & genomic medicine · 2018Article
- Common methods of measuring 'informed choice' in screening participation: Challenges and future directions.Preventive medicine reports · 2016Review
- Responsible implementation of expanded carrier screening.European journal of human genetics : EJHG · 2016Article
- Explaining variation in Down's syndrome screening uptake: comparing the Netherlands with England and Denmark using documentary analysis and expert stakeholder interviews.BMC health services research · 2014Article
- Consanguineous marriage and reproductive risk: attitudes and understanding of ethnic groups practising consanguinity in Western society.European journal of human genetics : EJHG · 2014Article
- Attitudes of health care professionals toward carrier screening for cystic fibrosis. A review of the literature.Journal of community genetics · 2014Article
- Carrier screening in preconception consultation in primary care.Journal of community genetics · 2012Article
- Perceived relevance of genetic carrier screening: observations of the role of health-related life experiences and stage of life in decision making.Journal of community genetics · 2012Article
- Genetic counselling for personalised medicine.Human genetics · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine the acceptability and feasibility of screening for carriers of cystic fibrosis in a primary care setting.
designFollow up study over 15 months of patients offered carrier testing by mouthwash.
settingA general practice in inner London. SUBJECTS: 5529 patients aged 18-45 invited by various methods and combinations of methods (letter, booklet, personal approach) for testing.
main outcome measuresUptake of screening, anxiety, and knowledge of test.
results957 (17%) invitees were screened over the 15 months. 28 carriers and no carrier couples were detected. Uptake rates were 12% (59/502 patients) among patients invited by letter and tested by appointment; 9% (47/496) among patients invited by letter, with leaflet, and tested by appointment; 4% (128/2953) among patients invited by letter six weeks before the end of the study and tested by appointment; 17% (81/471) among patients offered passive opportunistic testing; 70% (453/649) among patients offered active opportunistic testing; and 25% (22/88) among patients offered active opportunistic testing by appointment. A short term rise in anxiety among those given a positive test result had dissipated by three months. At three months about one fifth and one third of those given positive and negative results respectively did not understand their results correctly.
conclusionThese results suggest that the strongest variable in determining uptake of screening is the active approach by a health professional offering immediate testing. It remains to be resolved whether the high uptake rates achieved by active recruitment indicate a supply push for this new test rather than a demand from the population.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.