ArticleProceedings of the National Academy of Sciences of the United States of America1993
Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 138 citations in OpenAlex.
- MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches.Frontiers in pediatrics · 2017Review
- Discovery of MLL1 binding units, their localization to CpG Islands, and their potential function in mitotic chromatin.BMC genomics · 2013Article
- Functional specificity of CpG DNA-binding CXXC domains in mixed lineage leukemia.The Journal of biological chemistry · 2013Article
- The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain.Nature communications · 2011Article
- Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting.Blood · 2010Article
- CXXC finger protein 1 restricts the Setd1A histone H3K4 methyltransferase complex to euchromatin.The FEBS journal · 2010Article
- Review
- C/EBPbeta suppression by interruption of CUGBP1 resulting from a complex rearrangement of MLL.Cancer genetics and cytogenetics · 2007Article
- Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt-Mdm2-p53 pathway.Oncogene · 2005Article
- Reduced genomic cytosine methylation and defective cellular differentiation in embryonic stem cells lacking CpG binding protein.Molecular and cellular biology · 2005Article
- Expression of leukemic MLL fusion proteins in Drosophila affects cell cycle control and chromosome morphology.Oncogene · 2004Article
- MBD1, MBD2 and CGBP genes at chromosome 18q21 are infrequently mutated in human colon and lung cancers.Oncogene · 2003Article
- Review
- The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation.Nucleic acids research · 2002Article
- Article
- CpG binding protein is crucial for early embryonic development.Molecular and cellular biology · 2001Article
- Article
- The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10.Oncogene · 2001Article
- Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription.The EMBO journal · 2001Article
- Chromatin modification and disease.Journal of medical genetics · 2000Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
A series of translocation break points found in a subset of human acute leukemias have one of the breaks on human chromosome 11q23. This region has recently been cloned and a large gene, ALL-1, with homology to the Drosophila trithorax gene has been identified. This paper describes the cloning, sequencing, and mapping of the mouse homolog of ALL-1. We have found a motif present in All-1 that shows homology to the zinc-binding domain of DNA (cytosine-5) methyltransferases (EC 2.1.1.63). Sequence analysis of the murine All-1 gene has identified distinct regions of homology with the human ALL-1 gene; these highly conserved domains may define regions of functional significance in mammals. In addition, we have identified alternatively spliced forms of All-1 within one of the zinc-finger domains, suggesting that there may be different targets and/or functions for All-1 proteins. Finally, we report that All-1 resides in the proximal portion of mouse chromosome 9 and is a candidate for a mutation that results in skeletal transformations during embryonic development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.