ArticleProceedings of the National Academy of Sciences of the United States of America1993
U7 small nuclear RNA in C snurposomes of the Xenopus germinal vesicle.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 98 citations in OpenAlex.
- Control of noncoding RNA production and histone levels by a 5' tRNA fragment.Genes & development · 2020Article
- Coordinating cell cycle-regulated histone gene expression through assembly and function of the Histone Locus Body.RNA biology · 2017Review
- A conserved interaction that is essential for the biogenesis of histone locus bodies.The Journal of biological chemistry · 2014Article
- Article
- Pearls are novel Cajal body-like structures in the Xenopus germinal vesicle that are dependent on RNA pol III transcription.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Article
- Non-canonical Cajal bodies form in the nucleus of late stage avian oocytes lacking functional nucleolus.Histochemistry and cell biology · 2012Article
- Periodic expression of Sm proteins parallels formation of nuclear Cajal bodies and cytoplasmic snRNP-rich bodies.Histochemistry and cell biology · 2011Article
- Drosophila histone locus bodies form by hierarchical recruitment of components.The Journal of cell biology · 2011Article
- The Cajal body and histone locus body.Cold Spring Harbor perspectives in biology · 2010Review
- Coilin is essential for Cajal body organization in Drosophila melanogaster.Molecular biology of the cell · 2009Article
- Chromosome odds and ends.Annual review of cell and developmental biology · 2009Article
- U7 snRNAs: a computational survey.Genomics, proteomics & bioinformatics · 2007Article
- U2 snRNP binds intronless histone pre-mRNAs to facilitate U7-snRNP-dependent 3' end formation.Molecular cell · 2007Article
- Splicing-independent recruitment of spliceosomal small nuclear RNPs to nascent RNA polymerase II transcripts.The Journal of cell biology · 2007Article
- Review
- Review
- Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein.RNA (New York, N.Y.) · 2006Article
- The Drosophila melanogaster Cajal body.The Journal of cell biology · 2006Article
- Dynamic nature of cleavage bodies and their spatial relationship to DDX1 bodies, Cajal bodies, and gems.Molecular biology of the cell · 2006Article
- U7 snRNA mutations in Drosophila block histone pre-mRNA processing and disrupt oogenesis.RNA (New York, N.Y.) · 2006Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In the amphibian germinal vesicle small nuclear RNAs (snRNAs) occur in morphologically distinct structures called snurposomes. Three types (A, B, and C) have been distinguished on the basis of cytological appearance and snRNA composition. C snurposomes in Xenopus are spherical bodies ranging in diameter from < 1 microns to about 10 microns. They stain intensely with antibodies against trimethylguanosine and the small nuclear ribonucleoprotein-specific Sm antigen but give weak or negative in situ hybridization reactions for the snRNAs involved in pre-mRNA splicing (U1, U2, U4, U5, and U6). We show here that C snurposomes in the Xenopus germinal vesicle contain U7 snRNA, an snRNA of low abundance involved in processing the 3' end of histone pre-mRNA. Xenopus U7 is 58 nucleotides long and is capped at the 5' end with trimethylguanosine. C snurposomes are often associated with B snurposomes, which contain the splicing snRNAs but not U7; B and C snurposomes together constitute a morphologically complex structure known as a sphere or sphere organelle. Although most spheres and C snurposomes are extrachromosomal, a few are attached at the histone gene loci on chromosomes 8, 9, and 16. Because they contain U7 snRNA and occur at the sites of histone pre-mRNA synthesis, C snurposomes presumably play a role in processing histone transcripts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.