ArticleProceedings of the National Academy of Sciences of the United States of America1993
Localization of sequences controlling the spatial, temporal, and sex-specific expression of the esterase 6 locus in Drosophila melanogaster adults.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Post-eclosion growth in the Drosophila ejaculatory duct is driven by Juvenile hormone signaling and is essential for male fertility.Developmental biology · 2025Article
- Post-eclosion growth in thebioRxiv : the preprint server for biology · 2024Article
- Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin.Genetics · 2014Article
- Population genomic inferences from sparse high-throughput sequencing of two populations of Drosophila melanogaster.Genome biology and evolution · 2009Article
- Sustained post-mating response in Drosophila melanogaster requires multiple seminal fluid proteins.PLoS genetics · 2007Article
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- Three-dimensional imaging of Drosophila melanogaster.PloS one · 2007Article
- Molecular population genetics of the beta-esterase gene cluster of Drosophila melanogaster.Journal of genetics · 2003Article
- Nucleotide variation of the Est-6 gene region in natural populations of Drosophila melanogaster.Genetics · 2003Article
- Divergent and conserved features in the spatial expression of the Drosophila pseudoobscura esterase-5B gene and the esterase-6 gene of Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
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- Structure, expression and gene sequence of a juvenile hormone esterase-related protein from metamorphosing larvae of Trichoplusia ni.The Biochemical journal · 1994Article
- Associations of esterase 6 allozyme and activity variation with reproductive fitness in Drosophila melanogaster.Genetica · 1994Article
- Evolutionary genetics of Drosophila esterases.Genetica · 1993Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The esterase 6 gene (Est-6) of Drosophila melanogaster is expressed in a variety of tissues that differ between larval and adult stages and among related species. Variability in the level of expression of this locus among different species and strains and its species- and tissue-specific patterns of expression make it a useful system for studying the evolution of gene regulation in Drosophila. We have begun to determine the location of the regulatory regions of Est-6 by constructing deletion mutants of the 5' regions of the gene and transforming them back into flies. Deletion mutants of the putative 5' promoter regions of Est-6 were fused to the bacterial beta-galactosidase gene (lacZ) and assayed for their ability to direct tissue-specific expression in transformed D. melanogaster adults. We have identified four independently acting Est-6 regulatory regions that direct the expression of lacZ in (i) the ejaculatory duct; (ii) the adult salivary glands; (iii) the respiratory system, prefrons, antennae, and maxillary palps; and (iv) the ejaculatory bulb and prefrons. We also found a region near the start of transcription that directed expression of Est-6 in the cardia or proventriculus in some transformed lines.
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