ArticleProceedings of the National Academy of Sciences of the United States of America1993
Drosophila transforming growth factor beta superfamily proteins induce endochondral bone formation in mammals.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 227 citations in OpenAlex.
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- Transgenic Analyses in Drosophila Reveal That mCORL1 Is Functionally Distinct from mCORL2 and dCORL.G3 (Bethesda, Md.) · 2019Article
- Discovery of Heterotopic Bone-Inducing Activity in Hard Tissues and the TGF-β Superfamily.International journal of molecular sciences · 2018Review
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- TGF-β Family Signaling inCold Spring Harbor perspectives in biology · 2017Review
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- Bone Morphogenetic Proteins.Cold Spring Harbor perspectives in biology · 2016Review
- BMP signalling in skeletal development, disease and repair.Nature reviews. Endocrinology · 2016Review
- Comparative analysis of zebrafish bone morphogenetic proteins 2, 4 and 16: molecular and evolutionary perspectives.Cellular and molecular life sciences : CMLS · 2016Article
- Redundancy and Molecular Evolution: The Rapid Induction of Bone Formation by the Mammalian Transforming Growth Factor-β3 Isoform.Frontiers in physiology · 2016Review
- Solving the Measurement Problem and then Steppin' Out over the Line Riding the Rarest Italian: Crossing the Streams to Retrieve Stable Bioactivity in Majorana Bound States of Dialy zed Human Platelet Lysates.The open neurology journal · 2015Article
- A therapeutic potential for marine skeletal proteins in bone regeneration.Marine drugs · 2013Review
- Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy.Cellular and molecular life sciences : CMLS · 2013Review
- An inwardly rectifying K+ channel is required for patterning.Development (Cambridge, England) · 2012Article
- Hyperactive BMP signaling induced by ALK2(R206H) requires type II receptor function in a Drosophila model for classic fibrodysplasia ossificans progressiva.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Regulation of Dpp activity by tissue-specific cleavage of an upstream site within the prodomain.Developmental biology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both decapentaplegic (dpp) protein and 60A protein have been implicated in pattern formation during Drosophila melanogaster embryogenesis. Within the C-terminal domain, dpp and 60A are similar to human bone morphogenetic protein 2 (75% identity) and human osteogenic protein 1 (70% identity), respectively. Both recombinant human bone morphogenetic protein 2 and recombinant human osteogenic protein 1 have been shown to induce bone formation in vivo and to restore large diaphyseal segmental defects in various animal models. We examined whether the Drosophila proteins, dpp and 60A, have the capacity to induce bone formation in mammals by using the rat subcutaneous bone induction model. Highly purified recombinant dpp and 60A induced the formation of cartilage, bone, and bone marrow in mammals, as determined by histological observations and by measurements of the specific activity of alkaline phosphatase and calcium content of the implants, thereby demonstrating that related proteins from phylogenetically distant species are capable of inducing bone formation in mammals when placed in sites where progenitor cells are available.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.