Trial reportArchives of disease in childhood1993
Increased bone mineral content of preterm infants fed with a nutrient enriched formula after discharge from hospital.
Trial report in Archives of disease in childhood, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Nutrient-enriched formula versus standard formula for preterm infants following hospital discharge.The Cochrane database of systematic reviews · 2016Pooled it
- Working group reports: evaluation of the evidence to support practice guidelines for nutritional care of preterm infants-the Pre-B Project.The American journal of clinical nutrition · 2016Pooled it
- Nutrient needs and feeding of premature infants. Nutrition Committee, Canadian Paediatric Society.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 1995Guideline
- Increased gain in bone mineral content of preterm infants fed an isocaloric, protein-, and mineral-enriched postdischarge formula.European journal of nutrition · 2013Trial
- Bone mineralisation in premature infants cannot be predicted from serum alkaline phosphatase or serum phosphate.Archives of disease in childhood. Fetal and neonatal edition · 2002Trial
- Maturation of primary and permanent teeth in preterm infants.Archives of disease in childhood. Fetal and neonatal edition · 2000Trial
- Article
- Determinants of bone mass and size in 7-year-old former term, late-preterm, and preterm boys.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2009Article
- Postdischarge nutritional therapy.Journal of perinatology : official journal of the California Perinatal Association · 2006Review
- The effects of the introduction of a high-nutrient transitional formula on growth and development of very-low-birth-weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2002Article
- Effects of nutrients in human milk on the recipient premature infant.Journal of mammary gland biology and neoplasia · 1999Review
- Feeding premature infants after hospital discharge.Paediatrics & child health · 1998Article
- Mineral accretion in growing bones--a framework for the future?Archives of disease in childhood · 1995Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone disease with persistent reduced bone mineralisation is common in premature infants. To test the hypothesis that enhancement of nutritional intake after discharge from hospital improves bone mineralisation, 31 formula fed preterm infants were randomly assigned to receive standard or multinutrient enriched milk from the time of discharge. The calcium and phosphorus contents of the enriched milk were 70 and 35 mg/100 ml v 35 and 29 mg/100 ml for the standard formula. Bone mineral content was measured before discharge from hospital in 21 of the infants; there was no difference in the bone mineral content between the groups at that time (35 mg/cm for the two groups). There was a significant increase in bone mineral content for those infants receiving the enriched v standard formula at 3 and 9 months corrected postnatal age: at 3 months the bone mineral content was 83 v 63 mg/cm and at 9 months 115 v 95 mg/cm. The difference between the groups was thus maintained although not increased at a corrected age of 9 months, when the bone mineral content of infants fed the enriched but not the standard formula was no longer significantly different from that of normal infants after adjusting for body size. The difference was not explained by the larger body size in infants fed the enriched formula. The results suggest that the use of a special nutrient enriched postdischarge formula has a significant positive effect on bone growth and mineralisation during a period of rapid skeletal development.
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Registered trials
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