ArticlePflugers Archiv : European journal of physiology1993
Two types of potassium channel regulated by ATP in pancreatic B cells isolated from a type-2 diabetic human.
Article in Pflugers Archiv : European journal of physiology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 10 citations in OpenAlex.
- Type IIB PKA serves as the primary effector of Gs-coupled receptor-potentiated insulin secretion in mice by orchestrating ion channels and granule phenotype.Diabetologia · 2026Article
- cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells.The Journal of physiology · 2006Article
- Modulation of the excitability of cholinergic basal forebrain neurones by KATP channels.The Journal of physiology · 2004Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
Two types of K channel regulated by ATP were observed in pancreatic beta cells from a type-2 diabetic man. One type had a conductance of 67 pS at -70 mV in symmetrical 140 mM KCl and was inhibited by intracellular ATP with a half-maximal concentration of 40 microM. ATP inhibition was antagonised by ADP. Tolbutamide inhibited the whole-cell K currents half-maximally at 25 microM. This channel has properties similar to those found for the ATP-sensitive K channel in rodent and normal human beta cells. The second channel type observed was an ATP-activated K channel. It had a conductance of 37 pS at -70 mV in symmetrical 140 mM KCl and was activated half-maximally by 9 microM intracellular ATP. This channel was unaffected by 1 mM tolbutamide. In cell-attached patches, one beta cell out of four tested responded to 20 mM glucose with depolarization. The role of the ATP-activated K channel with respect to the (patho)physiology of the beta cell is uncertain.
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